Cytotoxic coumarins from Calophyllum dispar

Six coumarins have been isolated from the fruits and the stem bark of Calophyllum dispar (Clusiaceae). The structures of these minor components were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these coumarins exhibited a significant cytotoxic activity...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2001-10, Vol.58 (4), p.571-575
Main Authors: Guilet, David, Séraphin, Denis, Rondeau, David, Richomme, Pascal, Bruneton, Jean
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Biological and medical sciences
Calophyllum dispar
Chemical constitution
Clusiaceae
Clusiaceae - chemistry
Coumarins
Coumarins - chemistry
Coumarins - isolation & purification
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant physiology and development
Spectrum Analysis
Tumor Cells, Cultured
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Summary:Six coumarins have been isolated from the fruits and the stem bark of Calophyllum dispar (Clusiaceae). The structures of these minor components were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these coumarins exhibited a significant cytotoxic activity against KB cells. Six coumarins have been isolated from the fruits and the stem bark of Calophyllum dispar (Clusiaceae). Some of these coumarins exhibited a significant cytotoxic activity against KB cells.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(01)00285-0