Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis

Morphogenesis and cell differentiation in multicellular organisms often require accurate control of cell divisions. We show that a novel cell cycle regulator, tribbles, is critical for this control during Drosophila development. During oogenesis, the level of tribbles affects the number of germ cell...

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Bibliographic Details
Published in:Cell 2000-05, Vol.101 (5), p.511-522
Main Authors: Mata, Juan, Curado, Silvia, Ephrussi, Anne, Rørth, Pernille
Format: Article
Language:English
Subjects:
Animals
cdc25 Phosphatases - metabolism
cdc25 protein
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Cycle Proteins - physiology
Drosophila
Drosophila - embryology
Drosophila - physiology
Drosophila Proteins
Female
G2 Phase
gastrulation
Genes, Insect
Insect Proteins - genetics
Insect Proteins - metabolism
Insect Proteins - physiology
Mitosis - physiology
Morphogenesis
Ovary - embryology
Phosphoprotein Phosphatases - metabolism
Protein Tyrosine Phosphatases
Protein-Serine-Threonine Kinases
string protein
Transfection
Tribbles protein
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Summary:Morphogenesis and cell differentiation in multicellular organisms often require accurate control of cell divisions. We show that a novel cell cycle regulator, tribbles, is critical for this control during Drosophila development. During oogenesis, the level of tribbles affects the number of germ cell divisions as well as oocyte determination. The mesoderm anlage enters mitosis prematurely in tribbles mutant embryos, leading to gastrulation defects. We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway. By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)80861-2