Loading…
Neuroanatomy of Down's Syndrome: A High-Resolution MRI Study
OBJECTIVE: Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of region...
Saved in:
Published in: | The American journal of psychiatry 2001-10, Vol.158 (10), p.1659-1665 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-a549t-c13b3835e33a2cbb6de133d73f958730429224be32d2125ef3ea99e24997ecf73 |
---|---|
cites | cdi_FETCH-LOGICAL-a549t-c13b3835e33a2cbb6de133d73f958730429224be32d2125ef3ea99e24997ecf73 |
container_end_page | 1665 |
container_issue | 10 |
container_start_page | 1659 |
container_title | The American journal of psychiatry |
container_volume | 158 |
creator | Pinter, Joseph D. Eliez, Stephan Schmitt, J. Eric Capone, George T. Reiss, Allan L. |
description | OBJECTIVE: Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of regional brain volumes in Down's syndrome by using high-resolution magnetic resonance imaging (MRI), determine whether these volumetric abnormalities are present from childhood, and consider the relationship between neuroanatomic abnormalities and the cognitive profile of Down's syndrome. METHOD: Sixteen children and young adults with Down's syndrome (age range=5-23 years) were matched for age and gender with 15 normal comparison subjects. High-resolution MRI scans were quantitatively analyzed for measures of overall and regional brain volumes and by tissue composition. RESULTS: Consistent with prior imaging studies, subjects with Down's syndrome had smaller overall brain volumes, with disproportionately smaller cerebellar volumes and relatively larger subcortical gray matter volumes. Also noted was relative preservation of parietal lobe gray and temporal lobe white matter in subjects with Down's syndrome versus comparison subjects. No abnormalities in pattern of brain asymmetry were noted in Down's syndrome subjects. CONCLUSIONS: The results largely confirm findings of previous studies with respect to overall patterns of brain volumes in Down's syndrome and also provide new evidence for abnormal volumes of specific regional tissue components. The presence of these abnormalities from an early age suggests that fetal or early postnatal developmental differences may underlie the observed pattern of neuroanatomic abnormalities and contribute to the specific cognitive and developmental deficits seen in individuals with Down's syndrome. |
doi_str_mv | 10.1176/appi.ajp.158.10.1659 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71207400</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>86064066</sourcerecordid><originalsourceid>FETCH-LOGICAL-a549t-c13b3835e33a2cbb6de133d73f958730429224be32d2125ef3ea99e24997ecf73</originalsourceid><addsrcrecordid>eNqFkV2L1DAUhoMozuzoP1ikiOhVa3KSNM3izTJ-7MCoMKOwdyFtU7dD29SkZem_NzNTVLxYr0IOzzknbx6ELglOCBHpW933daIPfUJ4lhyLKZeP0JJwymMBkD1GS4wxxJLT2wW68P4QrpgKeIoWhHCRSSmX6N0XMzqrOz3YdopsFb23990bH-2nrnS2NVfRdXRT_7iLd8bbZhxq20Wfd5toP4zl9Aw9qXTjzfP5XKHvHz98W9_E26-fNuvrbaw5k0NcEJrTjHJDqYYiz9PSEEpLQSvJM0ExAwnAckOhBALcVNRoKQ0wKYUpKkFX6PV5bu_sz9H4QbW1L0zT6M7Y0StBAAsWwv0P5EJgxmQawJf_gAc7ui6EUACYpSkACRA7Q4Wz3jtTqd7VrXaTIlgdHaijAxUcqODgVAwOQtuLefaYt6b80zR_egBezYD2hW4qp7ui9n9xITmFgJEzdtry-30P7v4FGy2eXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220466221</pqid></control><display><type>article</type><title>Neuroanatomy of Down's Syndrome: A High-Resolution MRI Study</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>American Psychiatric Publishing Journals (1997-Present)</source><creator>Pinter, Joseph D. ; Eliez, Stephan ; Schmitt, J. Eric ; Capone, George T. ; Reiss, Allan L.</creator><creatorcontrib>Pinter, Joseph D. ; Eliez, Stephan ; Schmitt, J. Eric ; Capone, George T. ; Reiss, Allan L.</creatorcontrib><description>OBJECTIVE: Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of regional brain volumes in Down's syndrome by using high-resolution magnetic resonance imaging (MRI), determine whether these volumetric abnormalities are present from childhood, and consider the relationship between neuroanatomic abnormalities and the cognitive profile of Down's syndrome. METHOD: Sixteen children and young adults with Down's syndrome (age range=5-23 years) were matched for age and gender with 15 normal comparison subjects. High-resolution MRI scans were quantitatively analyzed for measures of overall and regional brain volumes and by tissue composition. RESULTS: Consistent with prior imaging studies, subjects with Down's syndrome had smaller overall brain volumes, with disproportionately smaller cerebellar volumes and relatively larger subcortical gray matter volumes. Also noted was relative preservation of parietal lobe gray and temporal lobe white matter in subjects with Down's syndrome versus comparison subjects. No abnormalities in pattern of brain asymmetry were noted in Down's syndrome subjects. CONCLUSIONS: The results largely confirm findings of previous studies with respect to overall patterns of brain volumes in Down's syndrome and also provide new evidence for abnormal volumes of specific regional tissue components. The presence of these abnormalities from an early age suggests that fetal or early postnatal developmental differences may underlie the observed pattern of neuroanatomic abnormalities and contribute to the specific cognitive and developmental deficits seen in individuals with Down's syndrome.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.158.10.1659</identifier><identifier>PMID: 11578999</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject><![CDATA[Adolescent ; Adult ; Adult and adolescent clinical studies ; Age Factors ; Biological and medical sciences ; Brain ; Brain - anatomy & histology ; Cerebellum - anatomy & histology ; Child ; Child clinical studies ; Child, Preschool ; Developmental disorders ; Down Syndrome - diagnosis ; Down's syndrome ; Downs syndrome ; Female ; Frontal Lobe - anatomy & histology ; Humans ; Intellectual deficiency ; Magnetic resonance imaging ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; Medical sciences ; Neuroanatomy ; Neurology ; NMR ; Nuclear magnetic resonance ; Parietal Lobe - anatomy & histology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Temporal Lobe - anatomy & histology]]></subject><ispartof>The American journal of psychiatry, 2001-10, Vol.158 (10), p.1659-1665</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Oct 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a549t-c13b3835e33a2cbb6de133d73f958730429224be32d2125ef3ea99e24997ecf73</citedby><cites>FETCH-LOGICAL-a549t-c13b3835e33a2cbb6de133d73f958730429224be32d2125ef3ea99e24997ecf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.158.10.1659$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.158.10.1659$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2855,21626,21627,21628,27924,27925,31000,77794,77799</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1124932$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11578999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinter, Joseph D.</creatorcontrib><creatorcontrib>Eliez, Stephan</creatorcontrib><creatorcontrib>Schmitt, J. Eric</creatorcontrib><creatorcontrib>Capone, George T.</creatorcontrib><creatorcontrib>Reiss, Allan L.</creatorcontrib><title>Neuroanatomy of Down's Syndrome: A High-Resolution MRI Study</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of regional brain volumes in Down's syndrome by using high-resolution magnetic resonance imaging (MRI), determine whether these volumetric abnormalities are present from childhood, and consider the relationship between neuroanatomic abnormalities and the cognitive profile of Down's syndrome. METHOD: Sixteen children and young adults with Down's syndrome (age range=5-23 years) were matched for age and gender with 15 normal comparison subjects. High-resolution MRI scans were quantitatively analyzed for measures of overall and regional brain volumes and by tissue composition. RESULTS: Consistent with prior imaging studies, subjects with Down's syndrome had smaller overall brain volumes, with disproportionately smaller cerebellar volumes and relatively larger subcortical gray matter volumes. Also noted was relative preservation of parietal lobe gray and temporal lobe white matter in subjects with Down's syndrome versus comparison subjects. No abnormalities in pattern of brain asymmetry were noted in Down's syndrome subjects. CONCLUSIONS: The results largely confirm findings of previous studies with respect to overall patterns of brain volumes in Down's syndrome and also provide new evidence for abnormal volumes of specific regional tissue components. The presence of these abnormalities from an early age suggests that fetal or early postnatal developmental differences may underlie the observed pattern of neuroanatomic abnormalities and contribute to the specific cognitive and developmental deficits seen in individuals with Down's syndrome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Cerebellum - anatomy & histology</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child, Preschool</subject><subject>Developmental disorders</subject><subject>Down Syndrome - diagnosis</subject><subject>Down's syndrome</subject><subject>Downs syndrome</subject><subject>Female</subject><subject>Frontal Lobe - anatomy & histology</subject><subject>Humans</subject><subject>Intellectual deficiency</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuroanatomy</subject><subject>Neurology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Parietal Lobe - anatomy & histology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Temporal Lobe - anatomy & histology</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqFkV2L1DAUhoMozuzoP1ikiOhVa3KSNM3izTJ-7MCoMKOwdyFtU7dD29SkZem_NzNTVLxYr0IOzzknbx6ELglOCBHpW933daIPfUJ4lhyLKZeP0JJwymMBkD1GS4wxxJLT2wW68P4QrpgKeIoWhHCRSSmX6N0XMzqrOz3YdopsFb23990bH-2nrnS2NVfRdXRT_7iLd8bbZhxq20Wfd5toP4zl9Aw9qXTjzfP5XKHvHz98W9_E26-fNuvrbaw5k0NcEJrTjHJDqYYiz9PSEEpLQSvJM0ExAwnAckOhBALcVNRoKQ0wKYUpKkFX6PV5bu_sz9H4QbW1L0zT6M7Y0StBAAsWwv0P5EJgxmQawJf_gAc7ui6EUACYpSkACRA7Q4Wz3jtTqd7VrXaTIlgdHaijAxUcqODgVAwOQtuLefaYt6b80zR_egBezYD2hW4qp7ui9n9xITmFgJEzdtry-30P7v4FGy2eXQ</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Pinter, Joseph D.</creator><creator>Eliez, Stephan</creator><creator>Schmitt, J. Eric</creator><creator>Capone, George T.</creator><creator>Reiss, Allan L.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Neuroanatomy of Down's Syndrome: A High-Resolution MRI Study</title><author>Pinter, Joseph D. ; Eliez, Stephan ; Schmitt, J. Eric ; Capone, George T. ; Reiss, Allan L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a549t-c13b3835e33a2cbb6de133d73f958730429224be32d2125ef3ea99e24997ecf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Cerebellum - anatomy & histology</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child, Preschool</topic><topic>Developmental disorders</topic><topic>Down Syndrome - diagnosis</topic><topic>Down's syndrome</topic><topic>Downs syndrome</topic><topic>Female</topic><topic>Frontal Lobe - anatomy & histology</topic><topic>Humans</topic><topic>Intellectual deficiency</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuroanatomy</topic><topic>Neurology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Parietal Lobe - anatomy & histology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Temporal Lobe - anatomy & histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinter, Joseph D.</creatorcontrib><creatorcontrib>Eliez, Stephan</creatorcontrib><creatorcontrib>Schmitt, J. Eric</creatorcontrib><creatorcontrib>Capone, George T.</creatorcontrib><creatorcontrib>Reiss, Allan L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinter, Joseph D.</au><au>Eliez, Stephan</au><au>Schmitt, J. Eric</au><au>Capone, George T.</au><au>Reiss, Allan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroanatomy of Down's Syndrome: A High-Resolution MRI Study</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>158</volume><issue>10</issue><spage>1659</spage><epage>1665</epage><pages>1659-1665</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of regional brain volumes in Down's syndrome by using high-resolution magnetic resonance imaging (MRI), determine whether these volumetric abnormalities are present from childhood, and consider the relationship between neuroanatomic abnormalities and the cognitive profile of Down's syndrome. METHOD: Sixteen children and young adults with Down's syndrome (age range=5-23 years) were matched for age and gender with 15 normal comparison subjects. High-resolution MRI scans were quantitatively analyzed for measures of overall and regional brain volumes and by tissue composition. RESULTS: Consistent with prior imaging studies, subjects with Down's syndrome had smaller overall brain volumes, with disproportionately smaller cerebellar volumes and relatively larger subcortical gray matter volumes. Also noted was relative preservation of parietal lobe gray and temporal lobe white matter in subjects with Down's syndrome versus comparison subjects. No abnormalities in pattern of brain asymmetry were noted in Down's syndrome subjects. CONCLUSIONS: The results largely confirm findings of previous studies with respect to overall patterns of brain volumes in Down's syndrome and also provide new evidence for abnormal volumes of specific regional tissue components. The presence of these abnormalities from an early age suggests that fetal or early postnatal developmental differences may underlie the observed pattern of neuroanatomic abnormalities and contribute to the specific cognitive and developmental deficits seen in individuals with Down's syndrome.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>11578999</pmid><doi>10.1176/appi.ajp.158.10.1659</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0002-953X |
ispartof | The American journal of psychiatry, 2001-10, Vol.158 (10), p.1659-1665 |
issn | 0002-953X 1535-7228 |
language | eng |
recordid | cdi_proquest_miscellaneous_71207400 |
source | Applied Social Sciences Index & Abstracts (ASSIA); American Psychiatric Publishing Journals (1997-Present) |
subjects | Adolescent Adult Adult and adolescent clinical studies Age Factors Biological and medical sciences Brain Brain - anatomy & histology Cerebellum - anatomy & histology Child Child clinical studies Child, Preschool Developmental disorders Down Syndrome - diagnosis Down's syndrome Downs syndrome Female Frontal Lobe - anatomy & histology Humans Intellectual deficiency Magnetic resonance imaging Magnetic Resonance Imaging - statistics & numerical data Male Medical sciences Neuroanatomy Neurology NMR Nuclear magnetic resonance Parietal Lobe - anatomy & histology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Temporal Lobe - anatomy & histology |
title | Neuroanatomy of Down's Syndrome: A High-Resolution MRI Study |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T20%3A33%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuroanatomy%20of%20Down's%20Syndrome:%20A%20High-Resolution%20MRI%20Study&rft.jtitle=The%20American%20journal%20of%20psychiatry&rft.au=Pinter,%20Joseph%20D.&rft.date=2001-10-01&rft.volume=158&rft.issue=10&rft.spage=1659&rft.epage=1665&rft.pages=1659-1665&rft.issn=0002-953X&rft.eissn=1535-7228&rft.coden=AJPSAO&rft_id=info:doi/10.1176/appi.ajp.158.10.1659&rft_dat=%3Cproquest_cross%3E86064066%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a549t-c13b3835e33a2cbb6de133d73f958730429224be32d2125ef3ea99e24997ecf73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=220466221&rft_id=info:pmid/11578999&rfr_iscdi=true |