Moderate hypothermia blunts the inflammatory response and reduces organ injury after acute haemorrhage

Background: Reduced body temperature is a common companion to trauma/haemorrhage. Several clinical studies have identified hypothermia as an independent risk variable predisposing to increased morbidity and mortality. At the same time it is known that most enzymatic reactions are downregulated at te...

Full description

Saved in:
Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2001-09, Vol.45 (8), p.994-1001
Main Authors: Gundersen, Y., Vaagenes, P., Pharo, A., Valø, E. T., Opstad, P. K.
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
cytokines
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Hemodynamics
hemorrhagic shock
Hypothalamo-Hypophyseal System - physiology
Hypothermia
Hypothermia, Induced
Inflammation - prevention & control
Intensive care medicine
Interleukin-10 - blood
Interleukin-6 - blood
Luminescent Measurements
Male
Medical sciences
Pituitary-Adrenal System - physiology
Rats
Rats, Sprague-Dawley
reactive oxygen species
Shock, Hemorrhagic - complications
Shock, Hemorrhagic - immunology
systemic inflammation
Tumor Necrosis Factor-alpha - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Reduced body temperature is a common companion to trauma/haemorrhage. Several clinical studies have identified hypothermia as an independent risk variable predisposing to increased morbidity and mortality. At the same time it is known that most enzymatic reactions are downregulated at temperatures below 37°C. Theoretically this should restrain the inflammatory response and protect the host from remote organ injury. The study was performed to test this hypothesis. Methods: Twenty‐six male Sprague Dawley rats were used for the experiments. Volume controlled haemorrhagic shock was induced by withdrawal of 2.5 ml blood/100 g body weight over 10 min. Half of the animals (n=13) were then cooled to 32.5–33°C, the other half (n=13) were kept normothermic (37.5±0.5°C). Seventy‐five minutes after initiation of bleeding, two‐thirds of the blood was retransfused. Thereafter the rats were observed for 2 h. Key substances of systemic inflammation were determined (plasma values of TNF‐α, IL‐6, IL‐10, and corticosterone; reactive oxygen species in peritoneal phagocytes), plasma markers of organ function and integrity (AST, ALT, αGST, creatinine, urea), and survival. Results: Hypothermia reduced the release of IL‐6 (P
ISSN:0001-5172
1399-6576
DOI:10.1034/j.1399-6576.2001.450812.x