Rising incidence of post-transplant lymphoproliferative disease in kidney transplant recipients

Background: The purpose of this study was to determine whether the incidence of post‐transplant lymphoproliferative disease (PTLD) has been increasing in renal transplant recipients in this centre. Methods: Prospectively gathered data were analysed to establish trends in the epidemiology of PTLD in...

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Bibliographic Details
Published in:British journal of surgery 2001-10, Vol.88 (10), p.1330-1334
Main Authors: Libertiny, G., Watson, C. J. E., Gray, D. W. R., Welsh, K. I., Morris, P. J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
England - epidemiology
Follow-Up Studies
Humans
Immunosuppression - adverse effects
Immunosuppressive Agents - adverse effects
Incidence
Kidney Transplantation - adverse effects
Logistic Models
Lymphoproliferative Disorders - epidemiology
Lymphoproliferative Disorders - etiology
Medical sciences
Middle Aged
Odds Ratio
Prospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
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Summary:Background: The purpose of this study was to determine whether the incidence of post‐transplant lymphoproliferative disease (PTLD) has been increasing in renal transplant recipients in this centre. Methods: Prospectively gathered data were analysed to establish trends in the epidemiology of PTLD in 1537 patients. Results: Overall, PTLD occurred in 2·3 per cent of renal transplant recipients. An increase in its incidence coincided with the introduction of cyclosporin in the 1980s. However, there was a further increase in the incidence of PTLD in the 1990s when the only change in immunosuppressive policy was the abandonment of pretransplantation blood transfusion. The latter increase was particularly pronounced in patients with early‐onset PTLD in whom it presented within 600 days after transplantation. Conclusion: The incidence of PTLD has been increasing in renal transplant recipients. The recent increase appears to be independent of cyclosporin and may reflect the reduction in pretransplant blood transfusion. Changes in the incidence of PTLD may also mirror changes in the epidemiology of non‐Hodgkin lymphoma in the general population. © 2001 British Journal of Surgery Society Ltd
ISSN:0007-1323
1365-2168
DOI:10.1046/j.0007-1323.2001.01924.x