Periodic alternating interface positioning to lower WBC contamination of apheresis platelet concentrates: a multicenter evaluation

BACKGROUND: A new software version of a cell separator (AS TEC 204, Fresenius) providing WBC‐reduced single‐donor plateletpheresis concentrates was tested. STUDY DESIGN AND METHODS: Dual‐needle apheresis procedures (n = 621) were performed in three centers, using either fixed interface positioning (...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2000-06, Vol.40 (6), p.687-692
Main Authors: Zeiler, T., Zingsem, J., Moog, R., Kretschmer, V., Eckstein, R., Müller, N., Eisenbeisz, F.
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Platelets
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Centrifugation - methods
Evaluation Studies as Topic
FIP = fixed interface positioning
Humans
Leukocyte Count
Leukocytes - immunology
Leukocytes - virology
Medical sciences
PAIP = periodic alternating interface positioning
PC(s) = platelet concentrate(s)
Plateletpheresis - instrumentation
PRP = platelet‐rich plasma
Quality Control
SD‐PC(s) = single‐donor PC(s)
Software
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:BACKGROUND: A new software version of a cell separator (AS TEC 204, Fresenius) providing WBC‐reduced single‐donor plateletpheresis concentrates was tested. STUDY DESIGN AND METHODS: Dual‐needle apheresis procedures (n = 621) were performed in three centers, using either fixed interface positioning (FIP) or periodic alternating interface positioning (PAIP). The other separation parameters (e.g., anticoagulant:whole‐blood ratio, and blood flow) were set individually. All platelet concentrates were evaluated for platelet yields and contaminating WBCs. RESULTS: The introduction of the PAIP resulted in a significant (p
ISSN:0041-1132
1537-2995
DOI:10.1046/j.1537-2995.2000.40060687.x