Dynamic behavior of glucose oxidase-containing microparticles of poly(ethylene glycol)-grafted cationic hydrogels in an environment of changing pH

Poly(diethylaminoethyl-g-ethylene glycol) microparticles were prepared by suspension polymerization of diethylaminoethyl methacrylate, poly(ethylene glycol) monomethacrylate and the crosslinking agent tetra(ethylene glycol) dimethacrylate in silicone oil using redox initiators. Particles of differen...

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Bibliographic Details
Published in:Biomaterials 2000-07, Vol.21 (14), p.1439-1450
Main Authors: Podual, Kairali, Doyle III, Francis J., Peppas, Nicholas A.
Format: Article
Language:English
Subjects:
Biocompatible Materials
Cationic hydrogels
Drug Carriers
Emulsion polymerization
Enzymes
Glucose Oxidase
Graft copolymers
Hydrogels
Hydrogels - chemistry
Hydrogen-Ion Concentration
Kinetics
Methacrylates - chemistry
Microparticles
Microspheres
Molecular weight
pH effects
Polyelectrolytes
Polyethylene glycols
Polyethylene Glycols - chemistry
Pulsatile swelling
Redox reactions
Relaxation
Structure-Activity Relationship
Synthesis (chemical)
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Summary:Poly(diethylaminoethyl-g-ethylene glycol) microparticles were prepared by suspension polymerization of diethylaminoethyl methacrylate, poly(ethylene glycol) monomethacrylate and the crosslinking agent tetra(ethylene glycol) dimethacrylate in silicone oil using redox initiators. Particles of different sizes, crosslinking ratios and graft molecular weights were prepared. The changes in the swelling of the particles were studied as the pH was changed between 3.0 and 7.4. The particles showed rapid swelling/deswelling dynamics in response to changes in pH. It was evident that faster response could be obtained from smaller particles. Changing the crosslinking ratio resulted in changes in the extent of swelling, as well as the speed of response. It was also found that longer graft lengths were responsible for increasing the effect of relaxation of the swelling of the network.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(00)00020-X