Thymic epithelial cells induce Fas-independent activation apoptosis of thymocytes

Co-cultivation of human thymocytes with homologous thymic epithelial cells (TEC) resulted in apoptosis of thymocytes and increase of CD25 expression. TEC supernatant also induced these effects. Fraction of apoptotic cells was enriched by CD69 + cells but not by CD95 + cells. Thymocytes of mice MRL-l...

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Bibliographic Details
Published in:Immunology letters 2001-10, Vol.78 (3), p.201-207
Main Authors: Sharova, N.I, Dzutsev, A.Kh, Litvina, M.M, Pleskovskaya, G.N, Kharchenko, T.Yu, Yarilin, A.A
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - immunology
CD25 antigen
CD95 antigen
Cell Adhesion - immunology
Cell Line
Cell Line, Transformed
Cells, Cultured
Coculture Techniques
Epithelial Cells - immunology
Fas antigen
Fas Ligand Protein
fas Receptor - biosynthesis
fas Receptor - genetics
fas Receptor - physiology
Fas-receptor
Humans
Infant
Lymphocyte Activation - genetics
Membrane Glycoproteins - biosynthesis
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Mutant Strains
Mutation - genetics
T-Lymphocytes - cytology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Thymic epithelial cells
Thymocytes
Thymus Gland - cytology
Thymus Gland - immunology
Thymus Gland - metabolism
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Summary:Co-cultivation of human thymocytes with homologous thymic epithelial cells (TEC) resulted in apoptosis of thymocytes and increase of CD25 expression. TEC supernatant also induced these effects. Fraction of apoptotic cells was enriched by CD69 + cells but not by CD95 + cells. Thymocytes of mice MRL-lpr/lpr bearing mutant form of gene Fas were sensitive to apoptosis induction in co-culture with TEC in the same degree as thymocytes of mice bearing Fas gene of wild type. Apoptosis of murine thymocytes can be induced by co-cultivation with both murine and human TEC.
ISSN:0165-2478
1879-0542
DOI:10.1016/S0165-2478(01)00253-X