Measles virus interactions with cellular receptors: Consequences for viral pathogenesis

Although CNS complications occuring early and late after acute measles are a serious problem and often fatal, the transient immunosuppression lasting for several weeks after the rash is the major cause of measles-related morbidity and mortality worldwide. This review is focused on the interactions o...

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Bibliographic Details
Published in:Journal of neurovirology 2001-10, Vol.7 (5), p.391-399
Main Author: Schneider-Schaulies, Volker ter Meulen, Sibylle Schneider-Schaulies, Jürgen
Format: Article
Language:English
Subjects:
Antigens, CD - physiology
Antigens, Surface - physiology
Brain - pathology
Brain - virology
CD150 antigen
CD46 antigen
Cytokines - physiology
Encephalitis, Viral - virology
Glycoproteins - physiology
Hemagglutinins, Viral - physiology
Humans
Immunocompromised Host
Immunoglobulins - physiology
Lymphocyte Activation
Lymphocytes - immunology
Lymphocytes - metabolism
Lymphocytes - virology
Lymphopenia - complications
Lymphopenia - immunology
Lymphopenia - virology
Measles virus
Measles virus - pathogenicity
Measles virus - physiology
Membrane Cofactor Protein
Membrane Fusion - physiology
Membrane Glycoproteins - physiology
Models, Biological
Neuroglia - virology
Neurons - metabolism
Neurons - virology
Opportunistic Infections - etiology
Pneumonia, Viral - virology
Receptors, Cell Surface
Receptors, Virus - physiology
Resting Phase, Cell Cycle
Signal Transduction
Signaling Lymphocytic Activation Molecule Family Member 1
Subacute Sclerosing Panencephalitis - immunology
Subacute Sclerosing Panencephalitis - virology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - pathology
T-Lymphocyte Subsets - virology
Viral Fusion Proteins - physiology
Viral Matrix Proteins - physiology
Viremia - virology
Virulence
Virus Replication
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Description
Summary:Although CNS complications occuring early and late after acute measles are a serious problem and often fatal, the transient immunosuppression lasting for several weeks after the rash is the major cause of measles-related morbidity and mortality worldwide. This review is focused on the interactions of measles virus (MV) with cellular receptors on neural and lymphoid cells which are important elements in viral pathogenesis. First, the cognate MV receptors, CD46 and CD150, are important components of viral tropism by mediating binding and entry. Second, however, additional unknown cellular surface molecules may (independently of viral uptake) after interaction with the MV glycoprotein complex act as signaling molecules and thereby modulate cellular survival, proliferation, and specific functions.
ISSN:1355-0284
1538-2443
DOI:10.1080/135502801753170246