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Measles virus interactions with cellular receptors: Consequences for viral pathogenesis
Although CNS complications occuring early and late after acute measles are a serious problem and often fatal, the transient immunosuppression lasting for several weeks after the rash is the major cause of measles-related morbidity and mortality worldwide. This review is focused on the interactions o...
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| Published in: | Journal of neurovirology 2001-10, Vol.7 (5), p.391-399 |
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| container_end_page | 399 |
| container_issue | 5 |
| container_start_page | 391 |
| container_title | Journal of neurovirology |
| container_volume | 7 |
| creator | Schneider-Schaulies, Volker ter Meulen, Sibylle Schneider-Schaulies, Jürgen |
| description | Although CNS complications occuring early and late after acute measles are a serious problem and often fatal, the transient immunosuppression lasting for several weeks after the rash is the major cause of measles-related morbidity and mortality worldwide. This review is focused on the interactions of measles virus (MV) with cellular receptors on neural and lymphoid cells which are important elements in viral pathogenesis. First, the cognate MV receptors, CD46 and CD150, are important components of viral tropism by mediating binding and entry. Second, however, additional unknown cellular surface molecules may (independently of viral uptake) after interaction with the MV glycoprotein complex act as signaling molecules and thereby modulate cellular survival, proliferation, and specific functions. |
| doi_str_mv | 10.1080/135502801753170246 |
| format | article |
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This review is focused on the interactions of measles virus (MV) with cellular receptors on neural and lymphoid cells which are important elements in viral pathogenesis. First, the cognate MV receptors, CD46 and CD150, are important components of viral tropism by mediating binding and entry. Second, however, additional unknown cellular surface molecules may (independently of viral uptake) after interaction with the MV glycoprotein complex act as signaling molecules and thereby modulate cellular survival, proliferation, and specific functions.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.1080/135502801753170246</identifier><identifier>PMID: 11582511</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Antigens, CD - physiology ; Antigens, Surface - physiology ; Brain - pathology ; Brain - virology ; CD150 antigen ; CD46 antigen ; Cytokines - physiology ; Encephalitis, Viral - virology ; Glycoproteins - physiology ; Hemagglutinins, Viral - physiology ; Humans ; Immunocompromised Host ; Immunoglobulins - physiology ; Lymphocyte Activation ; Lymphocytes - immunology ; Lymphocytes - metabolism ; Lymphocytes - virology ; Lymphopenia - complications ; Lymphopenia - immunology ; Lymphopenia - virology ; Measles virus ; Measles virus - pathogenicity ; Measles virus - physiology ; Membrane Cofactor Protein ; Membrane Fusion - physiology ; Membrane Glycoproteins - physiology ; Models, Biological ; Neuroglia - virology ; Neurons - metabolism ; Neurons - virology ; Opportunistic Infections - etiology ; Pneumonia, Viral - virology ; Receptors, Cell Surface ; Receptors, Virus - physiology ; Resting Phase, Cell Cycle ; Signal Transduction ; Signaling Lymphocytic Activation Molecule Family Member 1 ; Subacute Sclerosing Panencephalitis - immunology ; Subacute Sclerosing Panencephalitis - virology ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - pathology ; T-Lymphocyte Subsets - virology ; Viral Fusion Proteins - physiology ; Viral Matrix Proteins - physiology ; Viremia - virology ; Virulence ; Virus Replication</subject><ispartof>Journal of neurovirology, 2001-10, Vol.7 (5), p.391-399</ispartof><rights>2001 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-2d8fccbc598f1390d96df85bab509cf2a192cab7c88da005988bcf6484d0899a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11582511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider-Schaulies, Volker ter Meulen, Sibylle Schneider-Schaulies, Jürgen</creatorcontrib><title>Measles virus interactions with cellular receptors: Consequences for viral pathogenesis</title><title>Journal of neurovirology</title><addtitle>J Neurovirol</addtitle><description>Although CNS complications occuring early and late after acute measles are a serious problem and often fatal, the transient immunosuppression lasting for several weeks after the rash is the major cause of measles-related morbidity and mortality worldwide. 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immunology</subject><subject>Lymphopenia - virology</subject><subject>Measles virus</subject><subject>Measles virus - pathogenicity</subject><subject>Measles virus - physiology</subject><subject>Membrane Cofactor Protein</subject><subject>Membrane Fusion - physiology</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Models, Biological</subject><subject>Neuroglia - virology</subject><subject>Neurons - metabolism</subject><subject>Neurons - virology</subject><subject>Opportunistic Infections - etiology</subject><subject>Pneumonia, Viral - virology</subject><subject>Receptors, Cell Surface</subject><subject>Receptors, Virus - physiology</subject><subject>Resting Phase, Cell Cycle</subject><subject>Signal Transduction</subject><subject>Signaling Lymphocytic Activation Molecule Family Member 1</subject><subject>Subacute Sclerosing Panencephalitis - immunology</subject><subject>Subacute Sclerosing Panencephalitis - virology</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - pathology</subject><subject>T-Lymphocyte Subsets - virology</subject><subject>Viral Fusion Proteins - physiology</subject><subject>Viral Matrix Proteins - physiology</subject><subject>Viremia - virology</subject><subject>Virulence</subject><subject>Virus Replication</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMorq7-AQ_Sk7dqJh9tIl5k8QtWvCgeS5qmNkvb1KRV_Pdm2QUPgp5mYJ73ZXgQOgF8DljgC6CcYyIw5JxCjgnLdtABcCpSwhjdjXsE0kiwGToMYYUx0IyIfTQD4IJwgAP0-mhUaE1IPqyfQmL70XilR-v6kHzasUm0adupVT7xRpthdD5cJot4Ne-T6XUM1s6vw6pNBjU27s30JthwhPZq1QZzvJ1z9HJ787y4T5dPdw-L62WqGZAxJZWotS41l6IGKnEls6oWvFQlx1LXRIEkWpW5FqJSGEdMlLrOmGAVFlIqOkdnm97Bu_hRGIvOhvXPqjduCkUOJPZy_i8IglAqCYsg2YDauxC8qYvB2075rwJwsfZe_PYeQ6fb9qnsTPUT2YqOwNUGsH0U1qnGqHZstPKmWLnJ99HRX_3fgveRnA</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Schneider-Schaulies, Volker ter Meulen, Sibylle Schneider-Schaulies, Jürgen</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Measles virus interactions with cellular receptors: Consequences for viral pathogenesis</title><author>Schneider-Schaulies, Volker ter Meulen, Sibylle Schneider-Schaulies, Jürgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-2d8fccbc598f1390d96df85bab509cf2a192cab7c88da005988bcf6484d0899a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antigens, CD - physiology</topic><topic>Antigens, Surface - physiology</topic><topic>Brain - pathology</topic><topic>Brain - virology</topic><topic>CD150 antigen</topic><topic>CD46 antigen</topic><topic>Cytokines - physiology</topic><topic>Encephalitis, Viral - virology</topic><topic>Glycoproteins - physiology</topic><topic>Hemagglutinins, Viral - physiology</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunoglobulins - physiology</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - virology</topic><topic>Lymphopenia - complications</topic><topic>Lymphopenia - immunology</topic><topic>Lymphopenia - virology</topic><topic>Measles virus</topic><topic>Measles virus - pathogenicity</topic><topic>Measles virus - physiology</topic><topic>Membrane Cofactor Protein</topic><topic>Membrane Fusion - physiology</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Models, Biological</topic><topic>Neuroglia - 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This review is focused on the interactions of measles virus (MV) with cellular receptors on neural and lymphoid cells which are important elements in viral pathogenesis. First, the cognate MV receptors, CD46 and CD150, are important components of viral tropism by mediating binding and entry. Second, however, additional unknown cellular surface molecules may (independently of viral uptake) after interaction with the MV glycoprotein complex act as signaling molecules and thereby modulate cellular survival, proliferation, and specific functions.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>11582511</pmid><doi>10.1080/135502801753170246</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of neurovirology, 2001-10, Vol.7 (5), p.391-399 |
| issn | 1355-0284 1538-2443 |
| language | eng |
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| source | Springer Nature |
| subjects | Antigens, CD - physiology Antigens, Surface - physiology Brain - pathology Brain - virology CD150 antigen CD46 antigen Cytokines - physiology Encephalitis, Viral - virology Glycoproteins - physiology Hemagglutinins, Viral - physiology Humans Immunocompromised Host Immunoglobulins - physiology Lymphocyte Activation Lymphocytes - immunology Lymphocytes - metabolism Lymphocytes - virology Lymphopenia - complications Lymphopenia - immunology Lymphopenia - virology Measles virus Measles virus - pathogenicity Measles virus - physiology Membrane Cofactor Protein Membrane Fusion - physiology Membrane Glycoproteins - physiology Models, Biological Neuroglia - virology Neurons - metabolism Neurons - virology Opportunistic Infections - etiology Pneumonia, Viral - virology Receptors, Cell Surface Receptors, Virus - physiology Resting Phase, Cell Cycle Signal Transduction Signaling Lymphocytic Activation Molecule Family Member 1 Subacute Sclerosing Panencephalitis - immunology Subacute Sclerosing Panencephalitis - virology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology T-Lymphocyte Subsets - virology Viral Fusion Proteins - physiology Viral Matrix Proteins - physiology Viremia - virology Virulence Virus Replication |
| title | Measles virus interactions with cellular receptors: Consequences for viral pathogenesis |
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