Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients

Paraneoplastic limbic encephalitis (PLE) is a rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. The diagnosis is difficult because clinical markers are often lacking, and symptoms usually precede the diagnosis of cancer or mim...

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Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 2000-07, Vol.123 (7), p.1481-1494
Main Authors: Gultekin, S. Humayun, Rosenfeld, Myrna R., Voltz, Raymond, Eichen, Joseph, Posner, Jerome B., Dalmau, Josep
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Neoplasm - immunology
Antibodies, Neoplasm - metabolism
Autoantibodies - analysis
Behavior - physiology
Biological and medical sciences
Brain - pathology
Brain Neoplasms - immunology
Brain Neoplasms - pathology
Carcinoma, Small Cell - immunology
Carcinoma, Small Cell - pathology
Cerebrospinal Fluid - cytology
Child
encephalitis
Female
Humans
Immunohistochemistry
limbic
Limbic Encephalitis - immunology
Limbic Encephalitis - pathology
Limbic Encephalitis - psychology
Lung Neoplasms - immunology
Lung Neoplasms - pathology
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Nervous system involvement in other diseases. Miscellaneous
Neurology
Neurons - immunology
paraneoplastic
Paraneoplastic Syndromes, Nervous System - immunology
Paraneoplastic Syndromes, Nervous System - pathology
Paraneoplastic Syndromes, Nervous System - psychology
PLE = paraneoplastic limbic encephalitis
SCLC
SCLC = small-cell lung cancer
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Summary:Paraneoplastic limbic encephalitis (PLE) is a rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. The diagnosis is difficult because clinical markers are often lacking, and symptoms usually precede the diagnosis of cancer or mimic other complications. The frequency of antineuronal antibodies in patients with PLE has not been investigated. We examined the neurological symptoms and the causal tumours in 50 patients with PLE to determine the utility of paraneoplastic antibodies and other tests. The diagnosis of PLE required neuropathological examination or the presence of the four following criteria: (i) a compatible clinical picture; (ii) an interval of
ISSN:0006-8950
1460-2156
1460-2156
DOI:10.1093/brain/123.7.1481