Indium-111 capromab pendetide ( ProstaScint) uptake in neurofibromatosis

We report on the demonstration of nonspecific accumulation of indium-111 capromab pendetide (ProstaScint) in neurofibromas in a patient with a rising prostate-specific antigen level after prostatectomy. Although the immunoconjugate is targeted to a specific membrane antigen present in human prostate...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2000-07, Vol.56 (1), p.154-154
Main Authors: Khan, Angabeen, Caride, Vicente J
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - pharmacokinetics
Humans
Indium Radioisotopes
Male
Middle Aged
Neurofibromatoses - diagnostic imaging
Neurofibromatoses - metabolism
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - metabolism
Radionuclide Imaging
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Summary:We report on the demonstration of nonspecific accumulation of indium-111 capromab pendetide (ProstaScint) in neurofibromas in a patient with a rising prostate-specific antigen level after prostatectomy. Although the immunoconjugate is targeted to a specific membrane antigen present in human prostate carcinoma, nonspecific uptake can occur in other entities. Indium-111 capromab pendetide scintigraphy is a valuable diagnostic tool that should always be interpreted within the context of the clinical history and the laboratory and radiologic findings to avoid misinterpretation.
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(00)00531-8