The perinatal stress modification of the reactivity of the hypothalamo-hypophyseal-adrenal system

The literature data and the results of authors research work concerning long-term effects of prenatal stress and of early postnatal handling on the hypothalamic-pituitary-adrenal stress response are reviewed in the article. Functional state of that system, and the role of hormones, biogenic monoamin...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2000, Vol.46 (2), p.146-158
Main Authors: Reznikov, O H, Nosenko, N D
Format: Article
Language:Ukrainian
Subjects:
Acute Disease
Aging - physiology
Animals
Female
Hypothalamo-Hypophyseal System - physiopathology
Male
Pituitary-Adrenal System - physiopathology
Pregnancy
Prenatal Exposure Delayed Effects
Sex Characteristics
Stress, Physiological - physiopathology
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Summary:The literature data and the results of authors research work concerning long-term effects of prenatal stress and of early postnatal handling on the hypothalamic-pituitary-adrenal stress response are reviewed in the article. Functional state of that system, and the role of hormones, biogenic monoamines and glucocorticoid receptors of the brain in pathogenesis of its alteration are discussed. Special reference is made to gender- and age-related effects of pre- and postnatal stress. The body of evidences supports basic states of the brain hormone-neurotransmitter imprinting during early ontogenesis.
ISSN:2522-9028