Transplantation of renal precursor cells: a new therapeutic approach

The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated tha...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2000-06, Vol.14 (6), p.513-517
Main Author: Hammerman, M R
Format: Article
Language:English
Subjects:
Animals
Cell Transplantation - methods
Dendritic cells
Fetal Tissue Transplantation - methods
Humans
Kidney - cytology
Kidney - embryology
Kidney Transplantation - methods
Kidneys
Medicine
Rats
Transplants & implants
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Summary:The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated that the host immune response might be attenuated following the transplantation of renal precursor cells or embryonic kidneys (metanephroi) instead of developed (adult) kidneys. Transplanted metanephroi become chimeric organs in that their blood supply originates, at least in part, from the host. It is possible to transplant a developing metanephros, without the use of immunosuppression, from one rat to another. Transplanted metanephroi grow, develop, become vascularized, and function in host rats. Transplantation of metanephroi may be a promising novel therapeutic approach for the treatment of chronic renal failure.
ISSN:0931-041X
1432-198X
DOI:10.1007/s004670050805