Transplantation of renal precursor cells: a new therapeutic approach

The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated tha...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2000-06, Vol.14 (6), p.513-517
Main Author: Hammerman, M R
Format: Article
Language:English
Subjects:
Animals
Cell Transplantation - methods
Dendritic cells
Fetal Tissue Transplantation - methods
Humans
Kidney - cytology
Kidney - embryology
Kidney Transplantation - methods
Kidneys
Medicine
Rats
Transplants & implants
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c382t-2138471cde02788513480a15de059e95740cd8e731359474ee02efeabd6001673
cites
container_end_page 517
container_issue 6
container_start_page 513
container_title Pediatric nephrology (Berlin, West)
container_volume 14
creator Hammerman, M R
description The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated that the host immune response might be attenuated following the transplantation of renal precursor cells or embryonic kidneys (metanephroi) instead of developed (adult) kidneys. Transplanted metanephroi become chimeric organs in that their blood supply originates, at least in part, from the host. It is possible to transplant a developing metanephros, without the use of immunosuppression, from one rat to another. Transplanted metanephroi grow, develop, become vascularized, and function in host rats. Transplantation of metanephroi may be a promising novel therapeutic approach for the treatment of chronic renal failure.
doi_str_mv 10.1007/s004670050805
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71216778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71216778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-2138471cde02788513480a15de059e95740cd8e731359474ee02efeabd6001673</originalsourceid><addsrcrecordid>eNpdkE1Lw0AQhhdRbK0evcriwVt0Jrub3XiT-gkFLxV6C9vNhLakSdxNEP-9W9qDOpdh4OGdmYexS4RbBNB3AUBmGkCBAXXExihFmmBuFsdsDLnABCQuRuwshA0AGGWyUzZCMDrFPBuzx7m3Tehq2_S2X7cNbyvuqbE17zy5wYfWc0d1He655Q198X5F3nY09GvHbdf51rrVOTupbB3o4tAn7OP5aT59TWbvL2_Th1nihEn7JEVhpEZXEqTaGIVCGrCo4qxyypWW4EpDWqBQudSSIkcV2WWZAWCmxYTd7HPj2s-BQl9s12F3nW2oHUKhMY2YNhG8_gdu2sHHr0KRxoqmQEUo2UPOtyF4qorOr7fWfxcIxc5t8cdt5K8OocNyS-Uvei9T_ACUDnI0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222280505</pqid></control><display><type>article</type><title>Transplantation of renal precursor cells: a new therapeutic approach</title><source>Springer Nature</source><creator>Hammerman, M R</creator><creatorcontrib>Hammerman, M R</creatorcontrib><description>The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated that the host immune response might be attenuated following the transplantation of renal precursor cells or embryonic kidneys (metanephroi) instead of developed (adult) kidneys. Transplanted metanephroi become chimeric organs in that their blood supply originates, at least in part, from the host. It is possible to transplant a developing metanephros, without the use of immunosuppression, from one rat to another. Transplanted metanephroi grow, develop, become vascularized, and function in host rats. Transplantation of metanephroi may be a promising novel therapeutic approach for the treatment of chronic renal failure.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s004670050805</identifier><identifier>PMID: 10872196</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Animals ; Cell Transplantation - methods ; Dendritic cells ; Fetal Tissue Transplantation - methods ; Humans ; Kidney - cytology ; Kidney - embryology ; Kidney Transplantation - methods ; Kidneys ; Medicine ; Rats ; Transplants &amp; implants</subject><ispartof>Pediatric nephrology (Berlin, West), 2000-06, Vol.14 (6), p.513-517</ispartof><rights>IPNA - International Pediatric Nephrology Association New York, USA 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-2138471cde02788513480a15de059e95740cd8e731359474ee02efeabd6001673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10872196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammerman, M R</creatorcontrib><title>Transplantation of renal precursor cells: a new therapeutic approach</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated that the host immune response might be attenuated following the transplantation of renal precursor cells or embryonic kidneys (metanephroi) instead of developed (adult) kidneys. Transplanted metanephroi become chimeric organs in that their blood supply originates, at least in part, from the host. It is possible to transplant a developing metanephros, without the use of immunosuppression, from one rat to another. Transplanted metanephroi grow, develop, become vascularized, and function in host rats. Transplantation of metanephroi may be a promising novel therapeutic approach for the treatment of chronic renal failure.</description><subject>Animals</subject><subject>Cell Transplantation - methods</subject><subject>Dendritic cells</subject><subject>Fetal Tissue Transplantation - methods</subject><subject>Humans</subject><subject>Kidney - cytology</subject><subject>Kidney - embryology</subject><subject>Kidney Transplantation - methods</subject><subject>Kidneys</subject><subject>Medicine</subject><subject>Rats</subject><subject>Transplants &amp; implants</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpdkE1Lw0AQhhdRbK0evcriwVt0Jrub3XiT-gkFLxV6C9vNhLakSdxNEP-9W9qDOpdh4OGdmYexS4RbBNB3AUBmGkCBAXXExihFmmBuFsdsDLnABCQuRuwshA0AGGWyUzZCMDrFPBuzx7m3Tehq2_S2X7cNbyvuqbE17zy5wYfWc0d1He655Q198X5F3nY09GvHbdf51rrVOTupbB3o4tAn7OP5aT59TWbvL2_Th1nihEn7JEVhpEZXEqTaGIVCGrCo4qxyypWW4EpDWqBQudSSIkcV2WWZAWCmxYTd7HPj2s-BQl9s12F3nW2oHUKhMY2YNhG8_gdu2sHHr0KRxoqmQEUo2UPOtyF4qorOr7fWfxcIxc5t8cdt5K8OocNyS-Uvei9T_ACUDnI0</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Hammerman, M R</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Transplantation of renal precursor cells: a new therapeutic approach</title><author>Hammerman, M R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-2138471cde02788513480a15de059e95740cd8e731359474ee02efeabd6001673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Cell Transplantation - methods</topic><topic>Dendritic cells</topic><topic>Fetal Tissue Transplantation - methods</topic><topic>Humans</topic><topic>Kidney - cytology</topic><topic>Kidney - embryology</topic><topic>Kidney Transplantation - methods</topic><topic>Kidneys</topic><topic>Medicine</topic><topic>Rats</topic><topic>Transplants &amp; implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammerman, M R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Nursing &amp; Allied Health Database</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammerman, M R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplantation of renal precursor cells: a new therapeutic approach</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><addtitle>Pediatr Nephrol</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>14</volume><issue>6</issue><spage>513</spage><epage>517</epage><pages>513-517</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>The number of kidney transplantations performed per year is limited due to availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by hyperacute and acute rejection. It has been postulated that the host immune response might be attenuated following the transplantation of renal precursor cells or embryonic kidneys (metanephroi) instead of developed (adult) kidneys. Transplanted metanephroi become chimeric organs in that their blood supply originates, at least in part, from the host. It is possible to transplant a developing metanephros, without the use of immunosuppression, from one rat to another. Transplanted metanephroi grow, develop, become vascularized, and function in host rats. Transplantation of metanephroi may be a promising novel therapeutic approach for the treatment of chronic renal failure.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>10872196</pmid><doi>10.1007/s004670050805</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0931-041X
ispartof Pediatric nephrology (Berlin, West), 2000-06, Vol.14 (6), p.513-517
issn 0931-041X
1432-198X
language eng
recordid cdi_proquest_miscellaneous_71216778
source Springer Nature
subjects Animals
Cell Transplantation - methods
Dendritic cells
Fetal Tissue Transplantation - methods
Humans
Kidney - cytology
Kidney - embryology
Kidney Transplantation - methods
Kidneys
Medicine
Rats
Transplants & implants
title Transplantation of renal precursor cells: a new therapeutic approach
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T06%3A52%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transplantation%20of%20renal%20precursor%20cells:%20a%20new%20therapeutic%20approach&rft.jtitle=Pediatric%20nephrology%20(Berlin,%20West)&rft.au=Hammerman,%20M%20R&rft.date=2000-06-01&rft.volume=14&rft.issue=6&rft.spage=513&rft.epage=517&rft.pages=513-517&rft.issn=0931-041X&rft.eissn=1432-198X&rft_id=info:doi/10.1007/s004670050805&rft_dat=%3Cproquest_cross%3E71216778%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c382t-2138471cde02788513480a15de059e95740cd8e731359474ee02efeabd6001673%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=222280505&rft_id=info:pmid/10872196&rfr_iscdi=true