Atypical Cystic Lobules in Patients with Lobular Neoplasia

We analyzed the frequency and anatomic distribution of atypical cystic lobules (ACLs) in patients whose index biopsy specimen contained lobular neoplasia (LN). Thirty of 54 patients (56%) had ACLs in their index biopsy specimen. Five of the patients whose index biopsy lacked ACLs underwent an additi...

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Bibliographic Details
Published in:International journal of surgical pathology 2001-07, Vol.9 (3), p.201-206
Main Authors: Brogi, Edi, Oyama, Tetsunari, Koerner, Frederick C.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Breast cancer
Breast Neoplasms - pathology
Carcinoma in Situ - pathology
Carcinoma, Ductal, Breast - pathology
Carcinoma, Lobular - pathology
Female
Fibrocystic Breast Disease - pathology
Histology, Pathological
Humans
Middle Aged
Physiological aspects
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Summary:We analyzed the frequency and anatomic distribution of atypical cystic lobules (ACLs) in patients whose index biopsy specimen contained lobular neoplasia (LN). Thirty of 54 patients (56%) had ACLs in their index biopsy specimen. Five of the patients whose index biopsy lacked ACLs underwent an additional biopsy, and 4 of these patients had ACLs in an additional specimen, bringing the total number of patients having both ACLs and LN to 34 of 54 (62.9%). ACLs involved both breasts with equal frequency and neither the extent of the involvement nor the anatomic location of the LN paralleled the distribution of the ACLs. The presence of ACLs in patients with LN might explain its increased risk for the development of ductal carcinomas and their bilateral distribution.
ISSN:1066-8969
1940-2465
DOI:10.1177/106689690100900305