Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats

Aqueous, ethanolic and hexane fractions of Momordica cymbalaria fruits were prepared and given individually at different doses to different batches of rats (both normal and alloxan diabetic rats) after an overnight fast. The blood glucose levels were measured at 0, 1, 3, 5 and 7 h after the treatmen...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2001-11, Vol.78 (1), p.67-71
Main Authors: Kameswara Rao, B., Kesavulu, M.M., Apparao, Ch
Format: Article
Language:English
Subjects:
Alloxan
Animals
Antihyperglycemic activity
Biological and medical sciences
Blood Glucose - metabolism
Diabetes mellitus
Diabetes Mellitus, Experimental - drug therapy
Ethanol
General pharmacology
Hexanes
Hypoglycemic Agents - therapeutic use
Male
Medical sciences
Momordica
Momordica cymbalaria
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Solvents
Water
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Summary:Aqueous, ethanolic and hexane fractions of Momordica cymbalaria fruits were prepared and given individually at different doses to different batches of rats (both normal and alloxan diabetic rats) after an overnight fast. The blood glucose levels were measured at 0, 1, 3, 5 and 7 h after the treatment. The aqueous extract of Momordica cymbalaria at a dosage of 0.5 g/kg b.w. is showing maximal blood glucose lowering effect in diabetic rats. The same dosage did not produce any hypoglycemic activity in normal rats. The antihyperglycemic activity of Momordica cymbalaria fruit was compared with the treatment of Glibenclamide, an oral hypoglycemic agent.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(01)00324-5