Tumor necrosis factor(alpha) and insulin-like growth factor-I in the brain: is the whole greater than the sum of its parts?

The cytokine tumor necrosis factor(alpha) (TNFalpha) and the hormone insulin-like growth factor-I (IGF-I) have both been shown to regulate inflammatory events in the central nervous system (CNS). This review summarizes the seemingly independent roles of TNFalpha and IGF-I in promoting and inhibiting...

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Bibliographic Details
Published in:Journal of neuroimmunology 2001-10, Vol.119 (2), p.151-165
Main Authors: Venters, H D, Broussard, S R, Zhou, J H, Bluthé, R M, Freund, G G, Johnson, R W, Dantzer, R, Kelley, K W
Format: Article
Language:English
Subjects:
Animals
Brain - immunology
Brain Diseases - immunology
Humans
Insulin-Like Growth Factor I - immunology
Tumor Necrosis Factor-alpha - immunology
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Summary:The cytokine tumor necrosis factor(alpha) (TNFalpha) and the hormone insulin-like growth factor-I (IGF-I) have both been shown to regulate inflammatory events in the central nervous system (CNS). This review summarizes the seemingly independent roles of TNFalpha and IGF-I in promoting and inhibiting neurodegenerative diseases. We then offer evidence that the combined effects of IGF-I and TNFalpha on neuronal survival can be vastly different when both receptors are stimulated simultaneously, as is likely to occur in vivo. We propose the framework of a molecular model of hormone-cytokine receptor cross talk in which disparate cell surface receptors share intracellular substrates that regulate neuronal survival.
ISSN:0165-5728