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Brain and ventricle instability during psychotic episodes of the schizophrenias
Recent reports from serial brain scans suggest that the rate of ventricular expansion and/or brain atrophy may be accelerated in at least some schizophrenics. The authors assessed the effect of state changes upon such findings. Within-subject 3D MRIs were assessed for ventricular and brain volumes d...
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| Published in: | Schizophrenia research 2000-07, Vol.44 (1), p.11-23 |
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| container_title | Schizophrenia research |
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| creator | Garver, D.L Nair, T.R Christensen, J.D Holcomb, J.A Kingsbury, S.J |
| description | Recent reports from serial brain scans suggest that the
rate of ventricular expansion and/or brain atrophy may be accelerated in at least some schizophrenics. The authors assessed the effect of state changes upon such findings.
Within-subject 3D MRIs were assessed for ventricular and brain volumes during periods of [partial] remission and of exacerbation of psychosis. Additional scans at comparable within-subject SAPS were used to assess
rates of change in volumes that were independent of SAPS changes.
Correlations of changes of ventricle and brain volumes vs. change of SAPS cores between scans revealed that ventricle volumes
decreased during a period of psychotic exacerbation and
increased at a time of [partial] remission (
r
p=−0.666;
P |
| doi_str_mv | 10.1016/S0920-9964(00)00015-3 |
| format | article |
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rate of ventricular expansion and/or brain atrophy may be accelerated in at least some schizophrenics. The authors assessed the effect of state changes upon such findings.
Within-subject 3D MRIs were assessed for ventricular and brain volumes during periods of [partial] remission and of exacerbation of psychosis. Additional scans at comparable within-subject SAPS were used to assess
rates of change in volumes that were independent of SAPS changes.
Correlations of changes of ventricle and brain volumes vs. change of SAPS cores between scans revealed that ventricle volumes
decreased during a period of psychotic exacerbation and
increased at a time of [partial] remission (
r
p=−0.666;
P<0.0005); conversely, brain volumes
increased during psychotic exacerbation and
decreased at [partial] remission (
r
p=+0.448;
P=0.032). Scans at comparable SAPS scores suggested that the majority of patients had rates of ventricular expansion comparable to controls (0.9±0.6
cc/year), though two patients appeared to have rates of ventricular increase of 4.5±2.1
cc/year (Lilliefores
P=0.036; K-means clustering
F=17.75).
Exacerbation of psychosis in schizophrenia is accompanied by evidence of brain swelling, especially of periventricular brain, with incroachment of brain substance upon ventricular volumes. Controlled for state changes, the majority of schizophrenics show rates of ventricular expansion or brain atrophy indistinguishable from controls.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/S0920-9964(00)00015-3</identifier><identifier>PMID: 10867308</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Atrophy ; Biological and medical sciences ; Brain - pathology ; Brain atrophy ; Brain Edema - diagnosis ; Cerebral Ventricles - pathology ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Reference Values ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenic Psychology ; Ventricle expansion</subject><ispartof>Schizophrenia research, 2000-07, Vol.44 (1), p.11-23</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-12a3a2d9dd98fef0a9b1485e699a8aa9b5d955a1d0639ddb332af343571887b53</citedby><cites>FETCH-LOGICAL-c456t-12a3a2d9dd98fef0a9b1485e699a8aa9b5d955a1d0639ddb332af343571887b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1408877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10867308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garver, D.L</creatorcontrib><creatorcontrib>Nair, T.R</creatorcontrib><creatorcontrib>Christensen, J.D</creatorcontrib><creatorcontrib>Holcomb, J.A</creatorcontrib><creatorcontrib>Kingsbury, S.J</creatorcontrib><title>Brain and ventricle instability during psychotic episodes of the schizophrenias</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Recent reports from serial brain scans suggest that the
rate of ventricular expansion and/or brain atrophy may be accelerated in at least some schizophrenics. The authors assessed the effect of state changes upon such findings.
Within-subject 3D MRIs were assessed for ventricular and brain volumes during periods of [partial] remission and of exacerbation of psychosis. Additional scans at comparable within-subject SAPS were used to assess
rates of change in volumes that were independent of SAPS changes.
Correlations of changes of ventricle and brain volumes vs. change of SAPS cores between scans revealed that ventricle volumes
decreased during a period of psychotic exacerbation and
increased at a time of [partial] remission (
r
p=−0.666;
P<0.0005); conversely, brain volumes
increased during psychotic exacerbation and
decreased at [partial] remission (
r
p=+0.448;
P=0.032). Scans at comparable SAPS scores suggested that the majority of patients had rates of ventricular expansion comparable to controls (0.9±0.6
cc/year), though two patients appeared to have rates of ventricular increase of 4.5±2.1
cc/year (Lilliefores
P=0.036; K-means clustering
F=17.75).
Exacerbation of psychosis in schizophrenia is accompanied by evidence of brain swelling, especially of periventricular brain, with incroachment of brain substance upon ventricular volumes. Controlled for state changes, the majority of schizophrenics show rates of ventricular expansion or brain atrophy indistinguishable from controls.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain atrophy</subject><subject>Brain Edema - diagnosis</subject><subject>Cerebral Ventricles - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Reference Values</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenic Psychology</subject><subject>Ventricle expansion</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqF0E1v1DAQgGELUdFt4SeAfECoHALjOE7iUwUVH5Uq9QCcLceesIOyTvBkKy2_nnR3Bb31ZFl6xh69QrxU8E6Bqt9_A1tCYW1dXQC8BQBlCv1ErJRpdFEasE_F6h85FWfMv_YImmfiVEFbNxralbj9mD0l6VOUd5jmTGFASYln39FA807Gbab0U068C-txpiBxIh4jshx7Oa9RcljTn3FaZ0zk-bk46f3A-OJ4nosfnz99v_pa3Nx-ub76cFOEytRzoUqvfRltjLbtsQdvO1W1BmtrfeuXm4nWGK8i1HpBndal73WlTaPatumMPhdvDu9Oefy9RZ7dhjjgMPiE45Zdo0pla1Mt0BxgyCNzxt5NmTY-75wCd1_S7Uu6-0wOwO0jOb3MvTp-sO02GB9MHdIt4PUReA5-6LNPgfi_q2DZtFnY5YHhUuOOMDsOhClgpIxhdnGkRzb5C03QkFQ</recordid><startdate>20000707</startdate><enddate>20000707</enddate><creator>Garver, D.L</creator><creator>Nair, T.R</creator><creator>Christensen, J.D</creator><creator>Holcomb, J.A</creator><creator>Kingsbury, S.J</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000707</creationdate><title>Brain and ventricle instability during psychotic episodes of the schizophrenias</title><author>Garver, D.L ; Nair, T.R ; Christensen, J.D ; Holcomb, J.A ; Kingsbury, S.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-12a3a2d9dd98fef0a9b1485e699a8aa9b5d955a1d0639ddb332af343571887b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain atrophy</topic><topic>Brain Edema - diagnosis</topic><topic>Cerebral Ventricles - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reference Values</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenic Psychology</topic><topic>Ventricle expansion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garver, D.L</creatorcontrib><creatorcontrib>Nair, T.R</creatorcontrib><creatorcontrib>Christensen, J.D</creatorcontrib><creatorcontrib>Holcomb, J.A</creatorcontrib><creatorcontrib>Kingsbury, S.J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garver, D.L</au><au>Nair, T.R</au><au>Christensen, J.D</au><au>Holcomb, J.A</au><au>Kingsbury, S.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain and ventricle instability during psychotic episodes of the schizophrenias</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2000-07-07</date><risdate>2000</risdate><volume>44</volume><issue>1</issue><spage>11</spage><epage>23</epage><pages>11-23</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Recent reports from serial brain scans suggest that the
rate of ventricular expansion and/or brain atrophy may be accelerated in at least some schizophrenics. The authors assessed the effect of state changes upon such findings.
Within-subject 3D MRIs were assessed for ventricular and brain volumes during periods of [partial] remission and of exacerbation of psychosis. Additional scans at comparable within-subject SAPS were used to assess
rates of change in volumes that were independent of SAPS changes.
Correlations of changes of ventricle and brain volumes vs. change of SAPS cores between scans revealed that ventricle volumes
decreased during a period of psychotic exacerbation and
increased at a time of [partial] remission (
r
p=−0.666;
P<0.0005); conversely, brain volumes
increased during psychotic exacerbation and
decreased at [partial] remission (
r
p=+0.448;
P=0.032). Scans at comparable SAPS scores suggested that the majority of patients had rates of ventricular expansion comparable to controls (0.9±0.6
cc/year), though two patients appeared to have rates of ventricular increase of 4.5±2.1
cc/year (Lilliefores
P=0.036; K-means clustering
F=17.75).
Exacerbation of psychosis in schizophrenia is accompanied by evidence of brain swelling, especially of periventricular brain, with incroachment of brain substance upon ventricular volumes. Controlled for state changes, the majority of schizophrenics show rates of ventricular expansion or brain atrophy indistinguishable from controls.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10867308</pmid><doi>10.1016/S0920-9964(00)00015-3</doi><tpages>13</tpages></addata></record> |
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| source | ScienceDirect Freedom Collection |
| subjects | Adult Adult and adolescent clinical studies Atrophy Biological and medical sciences Brain - pathology Brain atrophy Brain Edema - diagnosis Cerebral Ventricles - pathology Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical sciences Middle Aged Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reference Values Schizophrenia Schizophrenia - diagnosis Schizophrenic Psychology Ventricle expansion |
| title | Brain and ventricle instability during psychotic episodes of the schizophrenias |
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