Antifungal Substances Against Pathogenic Fungi, Talaroconvolutins, from Talaromyces convolutus

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2000-06, Vol.63 (6), p.768-772
• Main Authors: Suzuki, Shohei, Hosoe, Tomoo, Nozawa, Koohei, Kawai, Ken-ichi, Yaguchi, Takashi, Udagawa, Shun-ichi
• Format: Article
• Language: English
• Subjects: Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Applied microbiology; Ascomycota - chemistry; Aspergillus fumigatus - drug effects; Aspergillus niger - drug effects; Biological and medical sciences; Candida albicans; Candida albicans - drug effects; Cryptococcus neoformans - drug effects; Fundamental and applied biological sciences. Psychology; Magnetic Resonance Spectroscopy; Microbiology; Models, Chemical; Naphthalenes - isolation & purification; Naphthalenes - pharmacology; Pyrones - isolation & purification; Pyrones - pharmacology; talaroconvolutin A; talaroconvolutins; Talaromyces convolutus; ZG-1494^a; ZG-1494a
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np990371x

The dichloromethane extract of Talaromyces convolutus cultivated on barley exhibited antifungal activity against Candida albicans. In the course of a search for the active compounds, four new tetramic acid derivatives, talaroconvolutins A (1), B (2), C (3), and D (4), were isolated along with ZG-1494α (5), and mitorubrin derivatives. The structures of talaroconvolutins A−D (1−4) were established on the basis of spectroscopic and chemical investigations and chemical correlations. The antifungal activity of the talaroconvolutins against the pathogenic fungi Aspergillus fumigates, Aspergillus niger, C. albicans, and Cryptococcus neoformans was determined.