Cognitive Performance in Relation to MRI Temporal Lobe Volume in Schizophrenic Patients and Healthy Control Subjects

The aim of this study was to identify whether specific deficits in cognitive processing are present in schizophrenia and whether these are related to the volume of temporal and limbic structures. Twenty-seven schizophrenic outpatients were compared with 19 matched control subjects. Compared with con...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2000-05, Vol.12 (2), p.251-256
Main Authors: Krabbendam, Lydia, Derix, Mayke M. A, Honig, Adriaan, Vuurman, Eric, Havermans, Rob, Wilmink, Jan T, Jolles, Jellemer
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Cognition - physiology
Female
Humans
Intelligence Tests
Limbic System - pathology
Magnetic Resonance Imaging
Male
Medical sciences
Neuropsychological Tests
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - pathology
Schizophrenic Psychology
Temporal Lobe - pathology
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Summary:The aim of this study was to identify whether specific deficits in cognitive processing are present in schizophrenia and whether these are related to the volume of temporal and limbic structures. Twenty-seven schizophrenic outpatients were compared with 19 matched control subjects. Compared with control subjects, patients performed complex tasks disproportionately worse than they performed simple tasks. No group differences were found with regard to temporal and limbic volume. Volume of the parahippocampal gyrus was correlated with cognitive performance. The findings are interpreted as evidence for a dysfunction in the maintenance of task-relevant information and the inhibition of irrelevant information.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.12.2.251