The (11;14)(q13;q32) translocation in multiple myeloma. A morphologic and immunohistochemical study

We identified 24 cases of multiple myeloma with the t(11;14)(q13;q32). In 22 cases, the t(11;14)(q13;q32) was part of a complex karyotype, and in 2 cases it was an isolated abnormality. All patients had clinical and laboratory features consistent with multiple myeloma. The median degree of plasma ce...

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Bibliographic Details
Published in:American journal of clinical pathology 2000-06, Vol.113 (6), p.831-837
Main Authors: Hoyer, J D, Hanson, C A, Fonseca, R, Greipp, P R, Dewald, G W, Kurtin, P J
Format: Article
Language:English
Subjects:
Adult
Aged
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 14
Cyclin D1 - metabolism
Female
Humans
Immunoenzyme Techniques
Male
Middle Aged
Multiple Myeloma - genetics
Multiple Myeloma - metabolism
Multiple Myeloma - pathology
Translocation, Genetic - genetics
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Summary:We identified 24 cases of multiple myeloma with the t(11;14)(q13;q32). In 22 cases, the t(11;14)(q13;q32) was part of a complex karyotype, and in 2 cases it was an isolated abnormality. All patients had clinical and laboratory features consistent with multiple myeloma. The median degree of plasma cell involvement in the bone marrow was 60%, and in 10 cases, the plasma cells had a lymphoplasmacytoid appearance. Of the 24 cases, 21 had intermediate or high proliferative rates based on labeling index studies. Immunohistochemical studies performed on all bone marrow biopsy specimens showed strong cyclin D1 nuclear positivity in 19 cases. There also was strong cyclin D1 nuclear positivity found in 6 of 30 additional cases without the t(11;14)(q13;q32) demonstrated by routine cytogenetics. The t(11;14)(q13;q32) in multiple myeloma results in overexpression of the cyclin D1 protein, which can be demonstrated by immunohistochemical stain. The cyclin D1 stain results in the additional cases of multiple myeloma suggest that the t(11;14)(q13;q32) may be more common than previously thought and may be missed by routine cytogenetics, particularly if the proliferative rate is low.
ISSN:0002-9173
DOI:10.1309/4W8E-8F4K-BHUP-UBE7