Of mice, men and motor neurons

The use of mouse models has been of particular importance in studying the pathogenesis of amyotrophic lateral sclerosis. Here, we describe both transgenic and classical mutants for which the genetic lesion is known. We draw attention, wherever possible, to pathological factors common to multiple mod...

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Bibliographic Details
Published in:Trends in genetics 2001-10, Vol.17 (10), p.S2-S6
Main Authors: Newbery, Helen J, Abbott, Catherine M
Format: Article
Language:English
Subjects:
amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - enzymology
Amyotrophic Lateral Sclerosis - genetics
Animals
Disease Models, Animal
Endothelial Growth Factors - genetics
Humans
Lymphokines - genetics
Mice
Mice, Knockout
Mice, Mutant Strains
Mice, Transgenic
motor neuron
Motor Neuron Disease - enzymology
Motor Neuron Disease - genetics
neurofilament
neuromuscular degeneration
superoxide dismutase
Superoxide Dismutase - genetics
Superoxide Dismutase-1
transgenic
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
wasted
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Description
Summary:The use of mouse models has been of particular importance in studying the pathogenesis of amyotrophic lateral sclerosis. Here, we describe both transgenic and classical mutants for which the genetic lesion is known. We draw attention, wherever possible, to pathological factors common to multiple models.
ISSN:0168-9525
DOI:10.1016/S0168-9525(01)02459-3