Activational effects of testosterone on cognitive function in men

Objectives: The effect of testosterone (T) on sexual function in men is well established. However, less is known about its effects on cognitive function. The aim of this study is to investigate the relationship between T levels and sex-typed cognitive abilities in both eugonadal and hypogonadal men....

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Bibliographic Details
Published in:Neuropsychologia 2001-01, Vol.39 (13), p.1385-1394
Main Authors: O'Connor, Daryl B, Archer, John, Hair, W.Morton, Wu, Frederick C.W
Format: Article
Language:English
Subjects:
Activational
Adult
Analysis of Variance
Cognition - drug effects
Estradiol
Eugonadal
Gonadal Steroid Hormones - administration & dosage
Gonadal Steroid Hormones - pharmacology
Humans
Hypogonadal
Hypogonadism - drug therapy
Hypogonadism - psychology
Injections, Intravenous
Male
Neuropsychological Tests
Single-Blind Method
Space Perception
Spatial ability
Testosterone - administration & dosage
Testosterone - analogs & derivatives
Testosterone - blood
Testosterone - pharmacology
Verbal fluency
Verbal Learning - drug effects
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Summary:Objectives: The effect of testosterone (T) on sexual function in men is well established. However, less is known about its effects on cognitive function. The aim of this study is to investigate the relationship between T levels and sex-typed cognitive abilities in both eugonadal and hypogonadal men. Design: A single-blind placebo-controlled design was employed in this study. Methods: Thirty healthy eugonadal men and seven hypogonadal men participated in the study. Eugonadal men were randomised into one of two treatment regimens: (1) active group – receiving 200 mg of T enanthate i.m. weekly for 8 weeks (raising T levels into the supraphysiological range) or (2) placebo group – receiving 200 mg of sodium chloride i.m. weekly for 8 weeks. The hypogonadal group received the physiological replacement dose of 200 mg T enanthate i.m. bi-weekly for 8 weeks. All groups underwent a battery of neuropsychological tests and had circulating T measured at baseline, and at weeks 4 and 8 during treatment. Results: A significant time by group interaction effect was found in the measure of spatial ability (i.e., block design test) indicating that the active group's performance declined significantly at week 4, compared to placebo group ( F(4,64)=3.78, P
ISSN:0028-3932
1873-3514
DOI:10.1016/S0028-3932(01)00067-7