Leg extensor power and dehydroepiandrosterone sulfate, insulin-like growth factor-I and testosterone in healthy active elderly people

We examined the association between quadriceps muscle function and serum levels of dehydroepiandrosterone sulphate (DHEAS), insulin-like growth factor I (IGF-I) and testosterone in a group of healthy elderly people. Fifty-three independent, community-dwelling elderly subjects (26 men and 27 women) a...

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Bibliographic Details
Published in:European journal of applied physiology 2000-05, Vol.82 (1-2), p.83-90
Main Authors: Kostka, T, Arsac, L M, Patricot, M C, Berthouze, S E, Lacour, J R, Bonnefoy, M
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Aging
Aging - physiology
Dehydroepiandrosterone Sulfate - blood
Exercise
Exercise Test
Female
Health care
Humans
Hydrocortisone - blood
Insulin
Insulin-Like Growth Factor I - analysis
Insulin-like growth factors
Leg
Male
Muscle function
Muscle strength
Muscle, Skeletal - physiology
Older people
Physical Fitness
Questionnaires
Regression Analysis
Testosterone
Testosterone - blood
Women
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Summary:We examined the association between quadriceps muscle function and serum levels of dehydroepiandrosterone sulphate (DHEAS), insulin-like growth factor I (IGF-I) and testosterone in a group of healthy elderly people. Fifty-three independent, community-dwelling elderly subjects (26 men and 27 women) aged from 66 to 84 years volunteered to participate in the study. Physical activity (PA) was evaluated by a questionnaire. Quadriceps maximal muscle power (Wmax) and optimal shortening velocity (v(opt)) were measured on a friction-loaded non-isokinetic cycle ergometer. The Wmax is expressed in relation to body mass (W(max/kg), W x kg(-1)), and in relation to the mass of the two quadriceps muscles (W(max/Quadr), W x kg(Quadr(-1))). In women, when adjusted for age, anthropometric measurements and PA indices, IGF-I correlated significantly with W(max/kg) (partial correlation: r = 0.59; P = 0.001), W(max/Quadr) (r = 0.58; P = 0.002) and v(opt) (r = 0.53; P = 0.004), whereas DHEAS was correlated significantly with W(max/kg) (r = 0.54; P = 0.003) and W(max/Quadr) (r = 0.58; P = 0.002). No such correlation was found in men. These findings indicate that in healthy elderly women lower values for quadriceps muscle Wmax and v(opt) are related, independently of age, anthropometric measurements and PA indices, to lower circulating levels of DHEAS and IGF-I.
ISSN:1439-6319
1439-6327
DOI:10.1007/s004210050655