Analytical techniques for determining biotin

Biotin is a vitamin of the B-complex, which plays an important biochemical role in every living cell. In the recent years, the interest in this vitamin has been rekindled, mainly due to its association with serious human disorders, such as the inherited syndrome multiple carboxylase deficiency, whic...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Chromatography A 2000-06, Vol.881 (1), p.331-343
Main Authors: Livaniou, Evangelia, Costopoulou, Danae, Vassiliadou, Irene, Leondiadis, Leondios, Nyalala, John O, Ithakissios, Dionyssis S, Evangelatos, Gregory P
Format: Article
Language:English
Subjects:
Biotin
Biotin - analysis
Humans
Vitamins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biotin is a vitamin of the B-complex, which plays an important biochemical role in every living cell. In the recent years, the interest in this vitamin has been rekindled, mainly due to its association with serious human disorders, such as the inherited syndrome multiple carboxylase deficiency, which can be successfully treated with biotin administration. Diagnosis of biotin deficiency as well as monitoring of biotin levels in biological fluids of patients receiving biotin treatment is crucial. Equally important is the determination of biotin levels in pharmaceutical preparations as well as in food and food supplement products, which constitute the main source of biotin in humans. Several analytical methods for measuring biotin in various samples, e.g. human fluids, pharmaceutical formulations, food material etc., have been reported in the literature. In this review, the most representative of these methods are presented, and their characteristics are evaluated.
ISSN:0021-9673
DOI:10.1016/S0021-9673(00)00118-7