New antineoplastic prenylhydroquinones. Synthesis and evaluation

Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their cytotoxic activity against some neoplastic cultured cell lines. A number of them have shown IC50 values under the microM level.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2000-05, Vol.8 (5), p.1027-1032
Main Authors: MOLINARI, A, OLIVA, A, AGUILERA, A. N, MIGUEL DEL CORRAL, J. M, CASTRO, M. A, GORDALIZA, M, GARCIA-GRAVALOS, D, SAN FELICIANO, A
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
General aspects
Humans
Hydroquinones - chemical synthesis
Hydroquinones - chemistry
Hydroquinones - pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Spectroscopy, Fourier Transform Infrared
Tumor Cells, Cultured
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Description
Summary:Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their cytotoxic activity against some neoplastic cultured cell lines. A number of them have shown IC50 values under the microM level.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(00)00032-8