Metabolic effects of fluoxetine in obese menopausal women

Our objective was to assess thermogenic action of fluoxetine (FL) in obese menopausal women, evaluating the effect of FL administration on resting energy expenditure (REE) and on glucose-induced thermogenesis both after acute administration (40 mg in single dose the evening before measurements) and...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2000-05, Vol.23 (5), p.280-286
Main Authors: BONDI, M, MENOZZI, R, BERTOLINI, M, VENNERI, M. G, DEL RIO, G
Format: Article
Language:English
Subjects:
Antidepressive Agents, Second-Generation - administration & dosage
Antidepressive Agents, Second-Generation - pharmacology
Antidepressive Agents, Second-Generation - therapeutic use
Biological and medical sciences
Blood Glucose - analysis
Body Temperature Regulation - drug effects
Double-Blind Method
Energy Metabolism - drug effects
Fasting
Female
Fluoxetine - administration & dosage
Fluoxetine - pharmacology
Fluoxetine - therapeutic use
General and cellular metabolism. Vitamins
Glucose - administration & dosage
Glucose Tolerance Test
Humans
Insulin - blood
Medical sciences
Menopause
Middle Aged
Obesity - diet therapy
Obesity - metabolism
Pharmacology. Drug treatments
Placebos
Weight Loss
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Summary:Our objective was to assess thermogenic action of fluoxetine (FL) in obese menopausal women, evaluating the effect of FL administration on resting energy expenditure (REE) and on glucose-induced thermogenesis both after acute administration (40 mg in single dose the evening before measurements) and after a 12- week period of diet treatment plus FL (60 mg per day) or placebo. It was a double-blind, placebo-controlled design both in acute and in chronic study. The subjects were 32 obese, otherwise healthy, menopausal women. The patients were assigned randomly to three groups, one performing an acute study protocol, in which resting and glucose-induced thermogenesis was measured after FL and placebo administration, performed in randomised order. The other two groups underwent dietary plus pharmacological treatment (FL or placebo, PL). Resting and glucose-induced thermogenesis was measured at baseline and after 12 weeks of treatment. The results showed that acute FL administration caused an increase in resting energy expenditure (PL: 5.35+/-0.18 vs FL: 5.53+/-0.24 KJ/min, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03343724