Association between depression and worse disease-specific functional status in outpatients with coronary artery disease

Background The objective of this study was to determine if depression is associated with worse disease-specific functional status in patients with coronary artery disease. The study was designed as a cross-sectional survey and 3-month longitudinal cohort. Methods and Results The study took place in...

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Bibliographic Details
Published in:The American heart journal 2000-07, Vol.140 (1), p.105-110
Main Authors: Spertus, John A., McDonell, Mary, Woodman, Catherine L., Fihn, Stephan D.
Format: Article
Language:English
Subjects:
Age Distribution
Aged
Angina Pectoris - epidemiology
Angina Pectoris - psychology
Biological and medical sciences
Cardiology. Vascular system
Cohort Studies
Comorbidity
Coronary Disease - diagnosis
Coronary Disease - epidemiology
Coronary Disease - psychology
Coronary heart disease
Cross-Sectional Studies
Depressive Disorder - diagnosis
Depressive Disorder - epidemiology
Depressive Disorder - physiopathology
Female
Heart
Humans
Incidence
Iowa - epidemiology
Male
Medical sciences
Middle Aged
Probability
Quality of Life
Reference Values
Risk Assessment
Severity of Illness Index
Sex Distribution
Sickness Impact Profile
Surveys and Questionnaires
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Summary:Background The objective of this study was to determine if depression is associated with worse disease-specific functional status in patients with coronary artery disease. The study was designed as a cross-sectional survey and 3-month longitudinal cohort. Methods and Results The study took place in outpatient clinics of 3 Veterans Administration hospitals. All 7282 enrollees were surveyed and 4560 (62.6%) returned baseline questionnaires, including a screening instrument for depression. Thirty-nine percent (n = 1793) reported evidence of coronary artery disease and 1282 patients (71.5%) returned the Seattle Angina Questionnaire; 1025 patients (80%) completed a subsequent 3-month series of instruments. Main outcome measures used were the Seattle Angina Questionnaire, a valid, reliable, and responsive disease-specific functional status measure for patients with coronary disease, and the Mental Health Inventory, a mental health screening instrument from the Short Form-36. Mental Health Inventory evidence of depression was associated with significantly worse disease-specific functional status. Depressed patients had more physical limitation (mean difference in Seattle Angina Questionnaire score = 16.9, P
ISSN:0002-8703
1097-6744
DOI:10.1067/mhj.2000.106600