Taxus canadensis abundant taxane : Conversion to paclitaxel and rearrangements

An efficient conversion of Taxus canadensis abundant taxane, 9-dihydro-13-acetylbaccatin III to baccatin III is described. Since the synthesis of paclitaxel from baccatin III has been reported, this work can be used for additional supply of this powerful anticancer drug. In addition, new taxanes der...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2000-06, Vol.8 (6), p.1269-1280
Main Authors: NIKOLAKAKIS, A, CARON, G, CHERESTES, A, SAURIOL, F, MAMER, O, ZAMIR, L. O
Format: Article
Language:English
Subjects:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Antineoplastic agents
Biological and medical sciences
Chemistry
Exact sciences and technology
General aspects
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Organic chemistry
Paclitaxel - analogs & derivatives
Paclitaxel - chemistry
Pharmacology. Drug treatments
Preparations and properties
Spectrometry, Mass, Fast Atom Bombardment
Terpenoids
Trees - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient conversion of Taxus canadensis abundant taxane, 9-dihydro-13-acetylbaccatin III to baccatin III is described. Since the synthesis of paclitaxel from baccatin III has been reported, this work can be used for additional supply of this powerful anticancer drug. In addition, new taxanes derived from skeletal rearrangements originating from oxidation reduction reactions of the Canadian yew major taxane, are reported.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(00)00056-0