The Role of RANTES in Meningococcal Disease

The chemokine RANTES (regulated on activation, normal T cell expressed and secreted) is a potent regulator of leukocyte trafficking. RANTES preferentially attracts mature CD4 cells as well as macrophages and eosinophils, but not neutrophils. In total, 128 children with meningococcal disease were pro...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-07, Vol.182 (1), p.363-366
Main Authors: Carrol, E. D., Thomson, A. P. J., Mobbs, K. J., Hart, C. A.
Format: Article
Language:English
Subjects:
Adolescent
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Cell Movement
Chemokine CCL5 - metabolism
Chemokines
Child
Child health services
Child, Preschool
Concise Communications
Cytokines
Cytokines - metabolism
Female
Human bacterial diseases
Humans
Infant
Infectious diseases
Intercellular Adhesion Molecule-1 - metabolism
Interleukins
Lymphocyte Activation
Male
Medical sciences
Meningococcal Infections - immunology
Meningococcal Infections - metabolism
Meningococcal Infections - pathology
Meningococcal Infections - physiopathology
Meningococcal meningitis
Neutrophils
Polymerase chain reaction
Prospective Studies
Sepsis
Septic shock
T lymphocytes
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Summary:The chemokine RANTES (regulated on activation, normal T cell expressed and secreted) is a potent regulator of leukocyte trafficking. RANTES preferentially attracts mature CD4 cells as well as macrophages and eosinophils, but not neutrophils. In total, 128 children with meningococcal disease were prospectively studied, and the role of RANTES in the pathophysiology of meningococcal disease was assessed. Plasma RANTES, interleukin (IL)-8, IL-6, IL-1 receptor agonist, and tumor necrosis factor-α were measured at admission. Severity of disease was stratified by the Glasgow meningococcal septicemia prognostic score (GMSPS). RANTES levels correlated significantly with IL-8 levels, admission lactate levels, platelets, prothrombin time, and activated partial thromboplastin time. RANTES levels were lower in children with severe disease (GMSPS ⩾ 8; P = .001), in those with septic shock (P < .0005), and in nonsurvivors (P = .048; Mann-Whitney test). RANTES is a potential mediator in the pathophysiology of meningococcal disease.
ISSN:0022-1899
1537-6613
DOI:10.1086/315680