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Analysis of env Sequence Evolution in Human Immunodeficiency Virus-Infected Patients Receiving Therapy with Nonnucleoside Reverse-Transcriptase Inhibitors
Nonnucleoside reverse-transcriptase inhibitors (NNRTIs) can rapidly select for drug-resistant human immunodeficiency virus type 1 (HIV-1) variants, although their effect on HIV-1 quasi-species diversity is unknown. To determine if changes in env gene diversification occur with NNRTI therapy, we used...
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Published in: | The Journal of infectious diseases 2000-07, Vol.182 (1), p.316-320 |
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container_title | The Journal of infectious diseases |
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creator | Dykes, C. Mootsikapun, P. Dexter, A. Berrios, L. Chiulli, M. Reichman, R. C. Demeter, L. M. |
description | Nonnucleoside reverse-transcriptase inhibitors (NNRTIs) can rapidly select for drug-resistant human immunodeficiency virus type 1 (HIV-1) variants, although their effect on HIV-1 quasi-species diversity is unknown. To determine if changes in env gene diversification occur with NNRTI therapy, we used the heteroduplex tracking assay (HTA) to study HIV-1 env sequence diversity in 2 groups of patients: those who were on no therapy or were on chronic antiretroviral therapy and those who had just initiated NNRTIs. Forty-nine paired samples from 46 patients were analyzed. Fourteen of 32 paired samples from the NNRTI group and 9 of 17 paired samples from the control group had HTA changes (P > .10). There was no correlation between HTA change and sampling time interval, baseline virus load, change in virus load, or development of NNRTI resistance. Thus, we found no significant correlation of NNRTI therapy with changes in env HTA patterns, suggesting that these treatments had little short-term impact on HIV-1 quasi-species diversity. |
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C. ; Demeter, L. M.</creator><creatorcontrib>Dykes, C. ; Mootsikapun, P. ; Dexter, A. ; Berrios, L. ; Chiulli, M. ; Reichman, R. C. ; Demeter, L. M.</creatorcontrib><description>Nonnucleoside reverse-transcriptase inhibitors (NNRTIs) can rapidly select for drug-resistant human immunodeficiency virus type 1 (HIV-1) variants, although their effect on HIV-1 quasi-species diversity is unknown. To determine if changes in env gene diversification occur with NNRTI therapy, we used the heteroduplex tracking assay (HTA) to study HIV-1 env sequence diversity in 2 groups of patients: those who were on no therapy or were on chronic antiretroviral therapy and those who had just initiated NNRTIs. Forty-nine paired samples from 46 patients were analyzed. Fourteen of 32 paired samples from the NNRTI group and 9 of 17 paired samples from the control group had HTA changes (P > .10). There was no correlation between HTA change and sampling time interval, baseline virus load, change in virus load, or development of NNRTI resistance. Thus, we found no significant correlation of NNRTI therapy with changes in env HTA patterns, suggesting that these treatments had little short-term impact on HIV-1 quasi-species diversity.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315691</identifier><identifier>PMID: 10882615</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS/HIV ; Antiretrovirals ; Biological and medical sciences ; Concise Communications ; DNA ; Drug Resistance, Microbial ; env gene ; Evolution ; Evolution, Molecular ; Genes, Viral ; Heteroduplex Analysis ; HIV 1 ; HIV Envelope Protein gp120 - genetics ; HIV Infections - drug therapy ; HIV Infections - genetics ; HIV Infections - virology ; HIV-1 - drug effects ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Polymerase chain reaction ; Protease inhibitors ; Reverse transcriptase inhibitors ; Reverse Transcriptase Inhibitors - pharmacology ; Sequence Analysis ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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C.</creatorcontrib><creatorcontrib>Demeter, L. M.</creatorcontrib><title>Analysis of env Sequence Evolution in Human Immunodeficiency Virus-Infected Patients Receiving Therapy with Nonnucleoside Reverse-Transcriptase Inhibitors</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Nonnucleoside reverse-transcriptase inhibitors (NNRTIs) can rapidly select for drug-resistant human immunodeficiency virus type 1 (HIV-1) variants, although their effect on HIV-1 quasi-species diversity is unknown. To determine if changes in env gene diversification occur with NNRTI therapy, we used the heteroduplex tracking assay (HTA) to study HIV-1 env sequence diversity in 2 groups of patients: those who were on no therapy or were on chronic antiretroviral therapy and those who had just initiated NNRTIs. Forty-nine paired samples from 46 patients were analyzed. Fourteen of 32 paired samples from the NNRTI group and 9 of 17 paired samples from the control group had HTA changes (P > .10). There was no correlation between HTA change and sampling time interval, baseline virus load, change in virus load, or development of NNRTI resistance. Thus, we found no significant correlation of NNRTI therapy with changes in env HTA patterns, suggesting that these treatments had little short-term impact on HIV-1 quasi-species diversity.</description><subject>AIDS/HIV</subject><subject>Antiretrovirals</subject><subject>Biological and medical sciences</subject><subject>Concise Communications</subject><subject>DNA</subject><subject>Drug Resistance, Microbial</subject><subject>env gene</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Genes, Viral</subject><subject>Heteroduplex Analysis</subject><subject>HIV 1</subject><subject>HIV Envelope Protein gp120 - genetics</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Polymerase chain reaction</subject><subject>Protease inhibitors</subject><subject>Reverse transcriptase inhibitors</subject><subject>Reverse Transcriptase Inhibitors - pharmacology</subject><subject>Sequence Analysis</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkt2O0zAQhSMEYrsLvAHIAom7gMdOHPtyWe3SShVUUH7EjeW4E-qSOMVOCn0VnhZDq4K44Wokn89HmnMmyx4AfQZUiuccSqHgVjaBkle5EMBvZxNKGctBKnWWnce4oZQWXFR3s7P0RTIB5ST7celNu48ukr4h6HfkLX4d0Vsk17u-HQfXe-I8mY6d8WTWdaPvV9g46xKzJ-9dGGM-8w3aAVdkYYb0PkTyBi26nfOfyXKNwWz35Jsb1uRV7_1oW-yjW2GCdhgi5stgfLTBbQcTkcz82tVu6EO8l91pTBvx_nFeZO9urpdX03z--uXs6nKe24LBkANWrEDFeV0U1piyUYbJBhpLsZQcOMgauJHMMGsKKSRCrQRH01Ql1Kyg_CJ7evDdhj7tHgfduWixbY3Hfoy6AsaZUNV_QZCgKC9EAh__A276MaSgo2aMK1pVEv642dDHGLDR2-A6E_YaqP7VqT50msBHR7ex7nD1F3YoMQFPjoCJ1rRNytO6eOIUBfp7zYcHahNTuieVU4B0Fyrp-UF3ccDvJ92EL1pUvCr19OMnPZ---DBni7le8J_fSsKh</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Dykes, C.</creator><creator>Mootsikapun, P.</creator><creator>Dexter, A.</creator><creator>Berrios, L.</creator><creator>Chiulli, M.</creator><creator>Reichman, R. C.</creator><creator>Demeter, L. M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Analysis of env Sequence Evolution in Human Immunodeficiency Virus-Infected Patients Receiving Therapy with Nonnucleoside Reverse-Transcriptase Inhibitors</title><author>Dykes, C. ; Mootsikapun, P. ; Dexter, A. ; Berrios, L. ; Chiulli, M. ; Reichman, R. C. ; Demeter, L. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of env Sequence Evolution in Human Immunodeficiency Virus-Infected Patients Receiving Therapy with Nonnucleoside Reverse-Transcriptase Inhibitors</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>182</volume><issue>1</issue><spage>316</spage><epage>320</epage><pages>316-320</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Nonnucleoside reverse-transcriptase inhibitors (NNRTIs) can rapidly select for drug-resistant human immunodeficiency virus type 1 (HIV-1) variants, although their effect on HIV-1 quasi-species diversity is unknown. To determine if changes in env gene diversification occur with NNRTI therapy, we used the heteroduplex tracking assay (HTA) to study HIV-1 env sequence diversity in 2 groups of patients: those who were on no therapy or were on chronic antiretroviral therapy and those who had just initiated NNRTIs. Forty-nine paired samples from 46 patients were analyzed. Fourteen of 32 paired samples from the NNRTI group and 9 of 17 paired samples from the control group had HTA changes (P > .10). There was no correlation between HTA change and sampling time interval, baseline virus load, change in virus load, or development of NNRTI resistance. Thus, we found no significant correlation of NNRTI therapy with changes in env HTA patterns, suggesting that these treatments had little short-term impact on HIV-1 quasi-species diversity.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10882615</pmid><doi>10.1086/315691</doi><tpages>5</tpages></addata></record> |
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subjects | AIDS/HIV Antiretrovirals Biological and medical sciences Concise Communications DNA Drug Resistance, Microbial env gene Evolution Evolution, Molecular Genes, Viral Heteroduplex Analysis HIV 1 HIV Envelope Protein gp120 - genetics HIV Infections - drug therapy HIV Infections - genetics HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Medical sciences Polymerase chain reaction Protease inhibitors Reverse transcriptase inhibitors Reverse Transcriptase Inhibitors - pharmacology Sequence Analysis Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viruses |
title | Analysis of env Sequence Evolution in Human Immunodeficiency Virus-Infected Patients Receiving Therapy with Nonnucleoside Reverse-Transcriptase Inhibitors |
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