Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications

The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syri...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2000-07, Vol.27 (6), p.292-297
Main Authors: Pozo, Lucia, Camacho, Francisco, Rios-Martin, Juan J., Diaz-Cano, Salvador J.
Format: Article
Language:English
Subjects:
Acrospiroma - chemistry
Acrospiroma - pathology
Adenoma, Sweat Gland - chemistry
Adenoma, Sweat Gland - pathology
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Antigens, Nuclear
Biological and medical sciences
Cell Division
Dermatology
Female
Humans
Ki-67 Antigen - analysis
Male
Medical sciences
Middle Aged
Mitotic Index
Nuclear Proteins - analysis
Sweat Gland Neoplasms - chemistry
Sweat Gland Neoplasms - pathology
Syringoma - chemistry
Syringoma - pathology
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR=MIB‐1 index), screening 10 consecutive high‐power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t‐test and analysis of variance (ANOVA) and considered significant if p
ISSN:0303-6987
1600-0560
DOI:10.1034/j.1600-0560.2000.027006292.x