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Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications
The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syri...
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| Published in: | Journal of cutaneous pathology 2000-07, Vol.27 (6), p.292-297 |
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| container_title | Journal of cutaneous pathology |
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| creator | Pozo, Lucia Camacho, Francisco Rios-Martin, Juan J. Diaz-Cano, Salvador J. |
| description | The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR=MIB‐1 index), screening 10 consecutive high‐power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t‐test and analysis of variance (ANOVA) and considered significant if p |
| doi_str_mv | 10.1034/j.1600-0560.2000.027006292.x |
| format | article |
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We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR=MIB‐1 index), screening 10 consecutive high‐power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t‐test and analysis of variance (ANOVA) and considered significant if p<0.05. PR was significantly higher in malignant (23.29±12.49) than in benign tumors (3.86±4.44) and in poroma‐nodular hidradenoma (4.99±3.34) than in spiradenoma‐cylindroma‐syringoma (1.91±1.67), but not by malignant tumor type. MFC was significantly higher in malignant (25.52±4.10) than in benign tumors (1.57±0.38), showing porocarcinomas the biggest MFC/10 HPF and malignant nodular hidradenomas the highest MFC/1000 cells. PR and MFC are useful malignancy criteria in skin TDD and should be evaluated by tumor cellularity to avoid potential misinterpretations related with tumor heterogeneity.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1034/j.1600-0560.2000.027006292.x</identifier><identifier>PMID: 10885405</identifier><identifier>CODEN: JCUPBN</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>Acrospiroma - chemistry ; Acrospiroma - pathology ; Adenoma, Sweat Gland - chemistry ; Adenoma, Sweat Gland - pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal ; Antigens, Nuclear ; Biological and medical sciences ; Cell Division ; Dermatology ; Female ; Humans ; Ki-67 Antigen - analysis ; Male ; Medical sciences ; Middle Aged ; Mitotic Index ; Nuclear Proteins - analysis ; Sweat Gland Neoplasms - chemistry ; Sweat Gland Neoplasms - pathology ; Syringoma - chemistry ; Syringoma - pathology ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of cutaneous pathology, 2000-07, Vol.27 (6), p.292-297</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4482-2d9b1f1a13748bdbd6bdf9e11ed832f0d89e779c5a67ba19beca9306a643b1783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1414886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10885405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pozo, Lucia</creatorcontrib><creatorcontrib>Camacho, Francisco</creatorcontrib><creatorcontrib>Rios-Martin, Juan J.</creatorcontrib><creatorcontrib>Diaz-Cano, Salvador J.</creatorcontrib><title>Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR=MIB‐1 index), screening 10 consecutive high‐power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t‐test and analysis of variance (ANOVA) and considered significant if p<0.05. PR was significantly higher in malignant (23.29±12.49) than in benign tumors (3.86±4.44) and in poroma‐nodular hidradenoma (4.99±3.34) than in spiradenoma‐cylindroma‐syringoma (1.91±1.67), but not by malignant tumor type. MFC was significantly higher in malignant (25.52±4.10) than in benign tumors (1.57±0.38), showing porocarcinomas the biggest MFC/10 HPF and malignant nodular hidradenomas the highest MFC/1000 cells. PR and MFC are useful malignancy criteria in skin TDD and should be evaluated by tumor cellularity to avoid potential misinterpretations related with tumor heterogeneity.</description><subject>Acrospiroma - chemistry</subject><subject>Acrospiroma - pathology</subject><subject>Adenoma, Sweat Gland - chemistry</subject><subject>Adenoma, Sweat Gland - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Monoclonal</subject><subject>Antigens, Nuclear</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitotic Index</subject><subject>Nuclear Proteins - analysis</subject><subject>Sweat Gland Neoplasms - chemistry</subject><subject>Sweat Gland Neoplasms - pathology</subject><subject>Syringoma - chemistry</subject><subject>Syringoma - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqVkE1v1DAQhi0EokvLX0A5VNwSxnHiD8QFllKQCm3VVhwtx3bA22wSbEfd_nu8zXbLlYsta555x_MgdIyhwECqd6sCU4AcagpFCQAFlAyAlqIsNs_QYl98jhZAgORUcHaAXoWwAsCU0_olOsDAeV1BvUB6absuG_3QudZ6Fd3QZ67Pwm064rQefMjuXPydmUlH1WXGtQmzfXQP6PtsVDFa34dM9SZV1a9-CNHpTI1j5_QDFI7Qi1Z1wb7e3Yfo5svJ9fJrfnZ--m358SzXVcXLvDSiwS1WmLCKN6YxtDGtsBhbw0nZguHCMiZ0rShrFBaN1UoQoIpWpMGMk0P0ds5N6_yZbIhy7YJO-6neDlOQDJekrkWZwA8zqP0QgretHL1bK38vMcitZLmSW49y61FuJcu9ZLlJ7W92c6Zmbc0_zbPVBBzvABW06lqveu3CE1fhinOasJMZu3Odvf-vP8jlzcXjK-Xkc44L0W72OcrfSsoIq-XPH6fyStSXl5-_X8tP5C8my6q7</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Pozo, Lucia</creator><creator>Camacho, Francisco</creator><creator>Rios-Martin, Juan J.</creator><creator>Diaz-Cano, Salvador J.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200007</creationdate><title>Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications</title><author>Pozo, Lucia ; Camacho, Francisco ; Rios-Martin, Juan J. ; Diaz-Cano, Salvador J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4482-2d9b1f1a13748bdbd6bdf9e11ed832f0d89e779c5a67ba19beca9306a643b1783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acrospiroma - chemistry</topic><topic>Acrospiroma - pathology</topic><topic>Adenoma, Sweat Gland - chemistry</topic><topic>Adenoma, Sweat Gland - pathology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Monoclonal</topic><topic>Antigens, Nuclear</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Ki-67 Antigen - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitotic Index</topic><topic>Nuclear Proteins - analysis</topic><topic>Sweat Gland Neoplasms - chemistry</topic><topic>Sweat Gland Neoplasms - pathology</topic><topic>Syringoma - chemistry</topic><topic>Syringoma - pathology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pozo, Lucia</creatorcontrib><creatorcontrib>Camacho, Francisco</creatorcontrib><creatorcontrib>Rios-Martin, Juan J.</creatorcontrib><creatorcontrib>Diaz-Cano, Salvador J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pozo, Lucia</au><au>Camacho, Francisco</au><au>Rios-Martin, Juan J.</au><au>Diaz-Cano, Salvador J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2000-07</date><risdate>2000</risdate><volume>27</volume><issue>6</issue><spage>292</spage><epage>297</epage><pages>292-297</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR=MIB‐1 index), screening 10 consecutive high‐power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t‐test and analysis of variance (ANOVA) and considered significant if p<0.05. PR was significantly higher in malignant (23.29±12.49) than in benign tumors (3.86±4.44) and in poroma‐nodular hidradenoma (4.99±3.34) than in spiradenoma‐cylindroma‐syringoma (1.91±1.67), but not by malignant tumor type. MFC was significantly higher in malignant (25.52±4.10) than in benign tumors (1.57±0.38), showing porocarcinomas the biggest MFC/10 HPF and malignant nodular hidradenomas the highest MFC/1000 cells. PR and MFC are useful malignancy criteria in skin TDD and should be evaluated by tumor cellularity to avoid potential misinterpretations related with tumor heterogeneity.</abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>10885405</pmid><doi>10.1034/j.1600-0560.2000.027006292.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Acrospiroma - chemistry Acrospiroma - pathology Adenoma, Sweat Gland - chemistry Adenoma, Sweat Gland - pathology Adolescent Adult Aged Aged, 80 and over Antibodies, Monoclonal Antigens, Nuclear Biological and medical sciences Cell Division Dermatology Female Humans Ki-67 Antigen - analysis Male Medical sciences Middle Aged Mitotic Index Nuclear Proteins - analysis Sweat Gland Neoplasms - chemistry Sweat Gland Neoplasms - pathology Syringoma - chemistry Syringoma - pathology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications |
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