Pachymeningitis in microscopic polyangiitis (MPA): A case report and a review of central nervous system involvement in MPA

A case of microscopic polyangiitis (MPA) with pachymeningitis is described. The patient had renal, skin, gallbladder and peripheral nervous system involvement, simultaneously with pachymeningitis. Necrotizing glomerulonephritis with crescent formation, and necrotizing small vessel vasculitis in the...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2000-05, Vol.18 (3), p.397-400
Main Authors: KONO, H, INOKUMA, S, NAKAYAMA, H, YAMAZAKI, J
Format: Article
Language:English
Subjects:
Antibodies, Antineutrophil Cytoplasmic - analysis
Biological and medical sciences
Brain Edema - complications
Brain Edema - immunology
Brain Edema - pathology
Dura Mater - blood supply
Dura Mater - immunology
Dura Mater - pathology
Female
Humans
Medical sciences
Meningitis - complications
Meningitis - immunology
Meningitis - pathology
Middle Aged
Peroxidase - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Vasculitis - complications
Vasculitis - immunology
Vasculitis - pathology
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Description
Summary:A case of microscopic polyangiitis (MPA) with pachymeningitis is described. The patient had renal, skin, gallbladder and peripheral nervous system involvement, simultaneously with pachymeningitis. Necrotizing glomerulonephritis with crescent formation, and necrotizing small vessel vasculitis in the kidney and skin were confirmed by biopsy. A highly elevated titer of antineutrophil cytoplasmic antibody for myeloperoxidase (MPO-ANCA) was observed. All of the clinical and laboratory abnormalities improved with high-dose pulse and conventional steroid therapy. The literature on central nervous system involvement in MPA and perinuclear-ANCA (p-ANCA)-related vasculitis is reviewed. This case serves to emphasize that pachymeningitis can occur as one of the features of MPA.
ISSN:0392-856X
1593-098X