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Pachymeningitis in microscopic polyangiitis (MPA): A case report and a review of central nervous system involvement in MPA
A case of microscopic polyangiitis (MPA) with pachymeningitis is described. The patient had renal, skin, gallbladder and peripheral nervous system involvement, simultaneously with pachymeningitis. Necrotizing glomerulonephritis with crescent formation, and necrotizing small vessel vasculitis in the...
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| Published in: | Clinical and experimental rheumatology 2000-05, Vol.18 (3), p.397-400 |
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| Language: | English |
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| container_end_page | 400 |
| container_issue | 3 |
| container_start_page | 397 |
| container_title | Clinical and experimental rheumatology |
| container_volume | 18 |
| creator | KONO, H INOKUMA, S NAKAYAMA, H YAMAZAKI, J |
| description | A case of microscopic polyangiitis (MPA) with pachymeningitis is described. The patient had renal, skin, gallbladder and peripheral nervous system involvement, simultaneously with pachymeningitis. Necrotizing glomerulonephritis with crescent formation, and necrotizing small vessel vasculitis in the kidney and skin were confirmed by biopsy. A highly elevated titer of antineutrophil cytoplasmic antibody for myeloperoxidase (MPO-ANCA) was observed. All of the clinical and laboratory abnormalities improved with high-dose pulse and conventional steroid therapy. The literature on central nervous system involvement in MPA and perinuclear-ANCA (p-ANCA)-related vasculitis is reviewed. This case serves to emphasize that pachymeningitis can occur as one of the features of MPA. |
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The patient had renal, skin, gallbladder and peripheral nervous system involvement, simultaneously with pachymeningitis. Necrotizing glomerulonephritis with crescent formation, and necrotizing small vessel vasculitis in the kidney and skin were confirmed by biopsy. A highly elevated titer of antineutrophil cytoplasmic antibody for myeloperoxidase (MPO-ANCA) was observed. All of the clinical and laboratory abnormalities improved with high-dose pulse and conventional steroid therapy. The literature on central nervous system involvement in MPA and perinuclear-ANCA (p-ANCA)-related vasculitis is reviewed. This case serves to emphasize that pachymeningitis can occur as one of the features of MPA.</description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 10895382</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Antibodies, Antineutrophil Cytoplasmic - analysis ; Biological and medical sciences ; Brain Edema - complications ; Brain Edema - immunology ; Brain Edema - pathology ; Dura Mater - blood supply ; Dura Mater - immunology ; Dura Mater - pathology ; Female ; Humans ; Medical sciences ; Meningitis - complications ; Meningitis - immunology ; Meningitis - pathology ; Middle Aged ; Peroxidase - immunology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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The patient had renal, skin, gallbladder and peripheral nervous system involvement, simultaneously with pachymeningitis. Necrotizing glomerulonephritis with crescent formation, and necrotizing small vessel vasculitis in the kidney and skin were confirmed by biopsy. A highly elevated titer of antineutrophil cytoplasmic antibody for myeloperoxidase (MPO-ANCA) was observed. All of the clinical and laboratory abnormalities improved with high-dose pulse and conventional steroid therapy. The literature on central nervous system involvement in MPA and perinuclear-ANCA (p-ANCA)-related vasculitis is reviewed. This case serves to emphasize that pachymeningitis can occur as one of the features of MPA.</description><subject>Antibodies, Antineutrophil Cytoplasmic - analysis</subject><subject>Biological and medical sciences</subject><subject>Brain Edema - complications</subject><subject>Brain Edema - immunology</subject><subject>Brain Edema - pathology</subject><subject>Dura Mater - blood supply</subject><subject>Dura Mater - immunology</subject><subject>Dura Mater - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Meningitis - complications</subject><subject>Meningitis - immunology</subject><subject>Meningitis - pathology</subject><subject>Middle Aged</subject><subject>Peroxidase - immunology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Vasculitis - complications</subject><subject>Vasculitis - immunology</subject><subject>Vasculitis - pathology</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpFkE9LxDAUxIMo7rr6FSQHET0U0maTNN4W8R-suAeFvZXXNNVIm9SkW6mf3qyueBoe82PmMXtomjJJEyLz9T6aEiqzJGd8PUFHIbwTknHGxSGapCSXjObZFH2tQL2NrbbGvpreBGwsbo3yLijXGYU714wQrR_v4nG1uLzCC6wgaOx153yPwVYY4jEY_YldjZW2vYcGW-0Htwk4jKHXbcwdXDPo2NRvO2LSMTqooQn6ZKcz9HJ783x9nyyf7h6uF8ukyyjvE0orngqguqS85kzVshaEMwkykyqfUyV0nuZlGYWVUArBqCjrap4xUVXAJZ2h89_czruPjQ590ZqgdNOA1fHBQqQZZZJswdMduClbXRWdNy34sfhbKwJnOwCCgqb2YJUJ_9ycEpqm9BtzDXVL</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>KONO, H</creator><creator>INOKUMA, S</creator><creator>NAKAYAMA, H</creator><creator>YAMAZAKI, J</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>Pachymeningitis in microscopic polyangiitis (MPA): A case report and a review of central nervous system involvement in MPA</title><author>KONO, H ; INOKUMA, S ; NAKAYAMA, H ; YAMAZAKI, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-33d617a3eb36f65cf9f70659a929c843c7e818bb7e85bab77537bfd4257dda693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antibodies, Antineutrophil Cytoplasmic - analysis</topic><topic>Biological and medical sciences</topic><topic>Brain Edema - complications</topic><topic>Brain Edema - immunology</topic><topic>Brain Edema - pathology</topic><topic>Dura Mater - blood supply</topic><topic>Dura Mater - immunology</topic><topic>Dura Mater - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Meningitis - complications</topic><topic>Meningitis - immunology</topic><topic>Meningitis - pathology</topic><topic>Middle Aged</topic><topic>Peroxidase - immunology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Vasculitis - complications</topic><topic>Vasculitis - immunology</topic><topic>Vasculitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KONO, H</creatorcontrib><creatorcontrib>INOKUMA, S</creatorcontrib><creatorcontrib>NAKAYAMA, H</creatorcontrib><creatorcontrib>YAMAZAKI, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KONO, H</au><au>INOKUMA, S</au><au>NAKAYAMA, H</au><au>YAMAZAKI, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pachymeningitis in microscopic polyangiitis (MPA): A case report and a review of central nervous system involvement in MPA</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>18</volume><issue>3</issue><spage>397</spage><epage>400</epage><pages>397-400</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>A case of microscopic polyangiitis (MPA) with pachymeningitis is described. The patient had renal, skin, gallbladder and peripheral nervous system involvement, simultaneously with pachymeningitis. Necrotizing glomerulonephritis with crescent formation, and necrotizing small vessel vasculitis in the kidney and skin were confirmed by biopsy. A highly elevated titer of antineutrophil cytoplasmic antibody for myeloperoxidase (MPO-ANCA) was observed. All of the clinical and laboratory abnormalities improved with high-dose pulse and conventional steroid therapy. The literature on central nervous system involvement in MPA and perinuclear-ANCA (p-ANCA)-related vasculitis is reviewed. This case serves to emphasize that pachymeningitis can occur as one of the features of MPA.</abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>10895382</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0392-856X |
| ispartof | Clinical and experimental rheumatology, 2000-05, Vol.18 (3), p.397-400 |
| issn | 0392-856X 1593-098X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71235909 |
| source | Freely Accessible Journals |
| subjects | Antibodies, Antineutrophil Cytoplasmic - analysis Biological and medical sciences Brain Edema - complications Brain Edema - immunology Brain Edema - pathology Dura Mater - blood supply Dura Mater - immunology Dura Mater - pathology Female Humans Medical sciences Meningitis - complications Meningitis - immunology Meningitis - pathology Middle Aged Peroxidase - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Vasculitis - complications Vasculitis - immunology Vasculitis - pathology |
| title | Pachymeningitis in microscopic polyangiitis (MPA): A case report and a review of central nervous system involvement in MPA |
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