Cerebral near infrared spectroscopy for the measurement of indocyanine green elimination in cirrhosis

• Published in: Alimentary pharmacology & therapeutics 2000-07, Vol.14 (7), p.923-928
• Main Authors: THERAPONDOS, G, PLEVRIS, J. N, STANLEY, A. J, PETERS, C. J, TEIG, M, HAYES, P. C
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Coloring Agents - analysis; Coloring Agents - pharmacokinetics; Digestive system; Humans; Indocyanine Green - analysis; Indocyanine Green - pharmacokinetics; Investigative techniques, diagnostic techniques (general aspects); Liver Cirrhosis - metabolism; Medical sciences; Metabolic Clearance Rate; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Reproducibility of Results; Spectrophotometry, Infrared - methods
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1046/j.1365-2036.2000.00789.x

Background: Indocyanine green (ICG) clearance is a useful indicator of hepatic function but most measurement methods are invasive. Aim: To validate a less invasive technique using cerebral near infrared spectrophotometry (NIRS) to measure ICG elimination, and to compare it with the established methods for the determination of ICG clearance in a group of normal controls and patients with cirrhosis. Method: NIRS was used to measure ICG elimination in 41 cirrhotic patients and nine healthy volunteers. The first 13 of the cirrhotic patients also had their ICG clearance measured by the conventional spectrophotometric technique. Results: NIRS ICG elimination rate (ICG‐k) and spectrophotometry ICG‐k values correlated strongly (r= 0.828, P