Massive rise in thyroglobulin with adult respiratory distress syndrome after embolisation of thyroid cancer metastasis

A patient with long-standing metastatic disease from a well differentiated papillary cell carcinoma of the thyroid underwent embolisation of a painful large sacral metastasis. Following embolisation she had a massive rise in circulating serum thyroglobulin (Tg) levels coinciding with the development...

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Bibliographic Details
Published in:British journal of radiology 2000-05, Vol.73 (869), p.547-549
Main Authors: Elshafie, O, Hussein, S, Jeans, W D, Woodhouse, N J
Format: Article
Language:English
Subjects:
Carcinoma, Papillary - secondary
Carcinoma, Papillary - therapy
Embolization, Therapeutic - adverse effects
Female
Humans
Middle Aged
Respiratory Distress Syndrome, Adult - blood
Respiratory Distress Syndrome, Adult - etiology
Spinal Neoplasms - secondary
Spinal Neoplasms - therapy
Thyroglobulin - blood
Thyroid Neoplasms - pathology
Thyroid Neoplasms - therapy
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Summary:A patient with long-standing metastatic disease from a well differentiated papillary cell carcinoma of the thyroid underwent embolisation of a painful large sacral metastasis. Following embolisation she had a massive rise in circulating serum thyroglobulin (Tg) levels coinciding with the development of adult respiratory distress syndrome (ARDS) on the tenth day without any other obvious cause. The patient subsequently recovered. The time course suggests that ARDS in this case might have resulted from aggregation of Tg molecules in the pulmonary microcirculation.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr.73.869.10884754