Pharmacokinetics of piperacillan after intramuscular injection in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus)

This study characterized and compared the pharmacokinetics of piperacillin after single 100 mg/kg i.m. injections in nine red-tailed hawks (Buteo jamaicensis) and five great horned owls (Bubo virginianus) over 48 hr by a modified agar well diffusion microbial inhibition assay. The mean maximum plasm...

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Bibliographic Details
Published in:Journal of zoo and wildlife medicine 2000-03, Vol.31 (1), p.47-51
Main Authors: Robbins, P K, Tell, L A, Needham, M L, Craigmill, A L
Format: Article
Language:English
Subjects:
Animals
Area Under Curve
Half-Life
Injections, Intramuscular - veterinary
Penicillins - administration & dosage
Penicillins - pharmacokinetics
Piperacillin - administration & dosage
Piperacillin - pharmacokinetics
Raptors - blood
Raptors - metabolism
Strigiformes - blood
Strigiformes - metabolism
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Summary:This study characterized and compared the pharmacokinetics of piperacillin after single 100 mg/kg i.m. injections in nine red-tailed hawks (Buteo jamaicensis) and five great horned owls (Bubo virginianus) over 48 hr by a modified agar well diffusion microbial inhibition assay. The mean maximum plasma piperacillin concentrations were 204 microg/ml and 221 microg/ml for the hawks and owls, respectively, and times of maximum concentrations were 15 min and 30 min, respectively. The calculated mean terminal elimination half-lives were 77 min in the hawks and 118 min in the owls. Area-under-the-curve values were 218 +/- 52 microg x hr/ml in the hawks and 444 +/- 104 microg x hr/ml in the owls. On the basis of the most common minimal inhibitory concentration (90%) for various bacterial isolates from clinical samples of 8 microg/ml, analysis of the data suggests that the maximum dosing interval for piperacillin at 100 mg/kg in medium sized raptors should be 4-6 hr.
ISSN:1042-7260