Regulators and effectors of the ARF GTPases

The small G proteins of the ARF family are key regulators of membrane dynamics. Many functions of ARF proteins in cells are being revealed by studies of their regulators and effectors. Significant progress has been made over the past year, with the identification of a surprisingly large family of no...

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Bibliographic Details
Published in:Current Opinion in Cell Biology 2000-08, Vol.12 (4), p.475-482
Main Authors: Donaldson, Julie G, Jackson, Catherine L
Format: Article
Language:English
Subjects:
ADP-ribosylation factor (ARF)
ADP-Ribosylation Factors - metabolism
Animals
Brefeldin A (BFA)
Endocytosis
Enzyme Activation
Golgi apparatus
GTP Phosphohydrolases - metabolism
GTPase
GTPase activating protein (GAP)
Guanine Nucleotide Exchange Factors - metabolism
Guanine nucleotide factor (GEF)
Membrane trafficking
Secretory pathway
Signal transduction
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Summary:The small G proteins of the ARF family are key regulators of membrane dynamics. Many functions of ARF proteins in cells are being revealed by studies of their regulators and effectors. Significant progress has been made over the past year, with the identification of a surprisingly large family of novel ARF GTPase-activating proteins. In addition, two new classes of effectors, the PIP kinases and a novel family of monomeric coat-like proteins have been discovered.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(00)00119-8