Local and systemic immune response to surgery under balanced anaesthesia in children

Summary We studied perioperative changes in the immune response and compared changes in the peripheral blood with those in the wound in 20 boys (0.5–3 years) during elective inguinal surgery under balanced anaesthesia. Blood samples were drawn before premedication, immediately, and 4 or 24 h after a...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric anesthesia 2000-07, Vol.10 (4), p.381-388
Main Authors: Mattila-Vuori, Armi, Salo, Matti, Iisalo, Eila, Pajulo, Olli, Viljanto, Jouko
Format: Article
Language:English
Subjects:
Analysis of Variance
Anesthesia
Anesthesia depending on patient's condition
Anesthesia, General
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
B-Lymphocytes - pathology
Biological and medical sciences
Blood
Child, Preschool
Cryptorchidism - surgery
Follow-Up Studies
Genital Diseases, Male - pathology
Genital Diseases, Male - surgery
Hernia, Inguinal - surgery
Humans
Hydrocortisone - blood
immune response
Immunity, Cellular - immunology
Infant
Linear Models
Lymphocyte Activation - drug effects
Lymphocyte Count
lymphocyte subsets
lymphocyte transformation
Male
Medical sciences
Mitogens - pharmacology
Preanesthetic Medication
T-Lymphocytes - pathology
T-Lymphocytes, Cytotoxic - pathology
T-Lymphocytes, Helper-Inducer - pathology
Testicular Hydrocele - surgery
wound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary We studied perioperative changes in the immune response and compared changes in the peripheral blood with those in the wound in 20 boys (0.5–3 years) during elective inguinal surgery under balanced anaesthesia. Blood samples were drawn before premedication, immediately, and 4 or 24 h after anaesthesia. Cells from the wound were harvested with the Cellstick device, removed from the wound 4 (n=10) or 24 h (n=10) after anaesthesia. We found decreased lymphocyte counts in the peripheral blood, increased percentages of activated T lymphocytes and B lymphocytes, and decreased percentages of total T lymphocytes, T helper cells and T cytotoxic cells. The percentages of T helper cells and B lymphocytes were lower in the wound than in blood. Mitogen‐induced lymphocyte proliferative responses decreased. This study demonstrates perioperative changes in the immune response in children and, as a new finding, that immune effector cells in the blood and in the wound are in a dynamic balance.
ISSN:1155-5645
1460-9592
DOI:10.1046/j.1460-9592.2000.00505.x