Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a)

Fragmentation pathways of Avermectins were studied by electron impact (EI), chemical ionisation (CI), electrospray ionisation (ESI) and by collision experiments. Structure characterisation was obtained using ESI combined with multi-stage (MS(n)) tandem mass spectrometry, analysis of homologues, and...

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Bibliographic Details
Published in:Rapid communications in mass spectrometry 2000, Vol.14 (14), p.1260-1265
Main Authors: Gianelli, L, Mellerio, G G, Siviero, E, Rossi, A, Cabri, W, Sogli, L
Format: Article
Language:English
Subjects:
Antiprotozoal Agents - chemistry
Ivermectin - analogs & derivatives
Ivermectin - chemistry
Mass Spectrometry
Streptomyces
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Summary:Fragmentation pathways of Avermectins were studied by electron impact (EI), chemical ionisation (CI), electrospray ionisation (ESI) and by collision experiments. Structure characterisation was obtained using ESI combined with multi-stage (MS(n)) tandem mass spectrometry, analysis of homologues, and effects on fragment masses of H/D exchange. By these approaches the structures of two new derivatives of Avermectins were characterised.
ISSN:0951-4198
DOI:10.1002/1097-0231(20000730)14:14<1260::aid-rcm20>3.0.co;2-%23