Growth factor receptor signalling: location, location, location

Ligand binding to plasma membrane receptors initiates a series of events culminating in a variety of changes in cellular phenotypes. Although numerous publications have documented the activation/inactivation of signalling molecules following receptor binding 1,2 , relatively few investigations have...

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Bibliographic Details
Published in:Trends in Cell Biology 2000-08, Vol.10 (8), p.343-348
Main Author: Leof, Edward B
Format: Article
Language:English
Subjects:
Animals
Cell signalling
G-protein-coupled receptor (GPCR)
Growth factor
Growth Substances - physiology
Humans
Receptors, Growth Factor - physiology
Ser/thr kinase
Signal Transduction - physiology
Tyrosine kinase
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Summary:Ligand binding to plasma membrane receptors initiates a series of events culminating in a variety of changes in cellular phenotypes. Although numerous publications have documented the activation/inactivation of signalling molecules following receptor binding 1,2 , relatively few investigations have focused on the cellular compartment responsible for either initiating or selecting the particular pathway that mediates the response 3 . Specifically, does receptor signalling occur only at the plasma membrane; is signalling dependent upon the location of defined endosome populations; or are components of both plasma membrane and endosomal activity operative depending upon the particular signalling pathway or cell type? This review addresses aspects of these questions by discussing the evidence supporting or contrasting the interplay between the endocytic and signalling systems for a subset of tyrosine kinase, serine/threonine kinase and G-protein-coupled receptors.
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(00)01795-5