Hyperglycaemia alters the endothelium-dependent relaxation of canine coronary arteries

The aim of the present study was to investigate the effects of experimental diabetes and hyperglycaemia per se on the endothelium‐dependent relaxation of isolated canine coronary arteries and to analyse the possible involvement of the cyclooxygenase pathway in the alterations induced by hyperglycaem...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 2000-07, Vol.169 (3), p.183-187
Main Authors: KOCSIS, E, PACHER, P, POSA, I, NIESZNER, E, POGATSA, G, KOLTAI, M. Z
Format: Article
Language:English
Subjects:
acetylcholine
Acetylcholine - pharmacology
Animals
Associated diseases and complications
Biological and medical sciences
Blood Glucose
coronary artery
Coronary Vessels - metabolism
Coronary Vessels - physiopathology
Cyclooxygenase Inhibitors - pharmacology
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Diabetes. Impaired glucose tolerance
Dinoprost - pharmacology
dog
Dogs
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
endothelium
Endothelium, Vascular - metabolism
Enzyme Inhibitors - pharmacology
experimental diabetes
Female
hyperglycaemia
Hyperglycemia - metabolism
in vitro
In Vitro Techniques
Indomethacin - pharmacology
Male
Medical sciences
Nitroarginine - pharmacology
Nitroprusside - pharmacology
Osmolar Concentration
Vasoconstriction - drug effects
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:The aim of the present study was to investigate the effects of experimental diabetes and hyperglycaemia per se on the endothelium‐dependent relaxation of isolated canine coronary arteries and to analyse the possible involvement of the cyclooxygenase pathway in the alterations induced by hyperglycaemia. Rings from the left anterior descending coronary arteries of 18 metabolically healthy, six alloxan‐diabetic and six insulin‐treated alloxan diabetic dogs were set up for isometric tension recording. Diabetic coronaries as well as healthy vessels subjected to in vitro hyperglycaemia (25.5 mmol L–1 glucose) showed impaired (P 
ISSN:0001-6772
1365-201X
DOI:10.1046/j.1365-201x.2000.00731.x