Muscle CT scan findings in McLeod syndrome and chorea-acanthocytosis

Computed tomography (CT) scans of lower leg muscles reveal a selective pattern of fat infiltration in the posterior compartment with spared gracilis, semitendinosus, and the lateral head of the gastrocnemius in both McLeod syndrome and chorea‐acanthocytosis, which are disorders characterized by the...

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Bibliographic Details
Published in:Muscle & nerve 2000-07, Vol.23 (7), p.1113-1116
Main Authors: Ishikawa, Shozo, Tachibana, Naoko, Tabata, Ken-Ichi, Fujimori, Naoharu, Hayashi, Rho-Ichi, Takahashi, Junko, Ikeda, Shu-Ichi, Hanyu, Norinao
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chorea - blood
Chorea - diagnostic imaging
Chorea - genetics
chorea-acanthocytosis
Creatine Kinase - blood
CT scan
Diseases of striated muscles. Neuromuscular diseases
Exons - genetics
Humans
Kell blood group typing
Kell Blood-Group System
Male
McLeod syndrome
Medical sciences
Middle Aged
muscle atrophy
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - enzymology
Neurology
Tomography, X-Ray Computed
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Summary:Computed tomography (CT) scans of lower leg muscles reveal a selective pattern of fat infiltration in the posterior compartment with spared gracilis, semitendinosus, and the lateral head of the gastrocnemius in both McLeod syndrome and chorea‐acanthocytosis, which are disorders characterized by the presence of circulating acanthocytes. The selectivity of affected muscles indicates that late onset and slowly progressive muscular atrophy in both diseases could be a consequence of primary myopathy. Asymmetrical muscle involvement may be seen during the process of degeneration only in McLeod syndrome, however, and may be helpful in distinguishing this disease from chorea‐acanthocytosis. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1113–1116, 2000
ISSN:0148-639X
1097-4598
DOI:10.1002/1097-4598(200007)23:7<1113::AID-MUS15>3.0.CO;2-6