Autologous blood donation with recombinant human erythropoietin for abdominal aortic aneurysm surgery

We evaluated the efficacy of autologous blood donation using recombinant human erythropoietin for elective abdominal aortic aneurysm (AAA) surgery regarding postoperative recovery. Twenty-five AAA patients who completed surgery without receiving a homologous blood transfusion were divided into two g...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2000-01, Vol.30 (6), p.511-515
Main Authors: Komai, H, Naito, Y, Iwasaki, Y, Iwahashi, M, Fujiwara, K, Noguchi, Y
Format: Article
Language:English
Subjects:
Aged
Aortic Aneurysm, Abdominal - surgery
Blood Transfusion, Autologous
Case-Control Studies
Defecation
Elective Surgical Procedures
Erythropoietin - therapeutic use
Female
Food
Hematocrit
Humans
Male
Postoperative Period
Recombinant Proteins
Time Factors
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Summary:We evaluated the efficacy of autologous blood donation using recombinant human erythropoietin for elective abdominal aortic aneurysm (AAA) surgery regarding postoperative recovery. Twenty-five AAA patients who completed surgery without receiving a homologous blood transfusion were divided into two groups, consisting of a control group (n = 12) who did not bank any autologous blood, and a donation group (n = 13) who did bank more than 800 ml of autologous blood with the use of erythropoietin. The hematocrit (Ht) level of the control group decreased from 41.1% +/- 1.2% before the operation to 36.2% +/- 0.9% just afterwards (P > 0.01). In the donation group, however, the Ht did not change significantly during either the donation period or the perioperative period. The postoperative period before oral food intake and natural defecation were both significantly shorter in the donation group than in the control group. The first day of mobilization was also earlier in the donation group. In conclusion, autologous blood donation using erythropoietin for AAA surgery is therefore considered to promote the early recovery of patients.
ISSN:0941-1291
1436-2813
DOI:10.1007/s005950070117