Maternal Hypothyroidism in Autoimmune Thyroiditis and the Prognosis of Infants

We evaluated the developmental prognosis of 31 infants born to mothers with autoimmune thyroiditis. Four of the babies developed transient neonatal hypothyroidism. Their mothers all had low thyroid hormone concentrations during pregnancy. Neonatal thyroid function tended to correlate with maternal t...

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Bibliographic Details
Published in:Endocrine Journal 2000, Vol.47(SupplMarch), pp.S133-S135
Main Authors: WADA, KYOKO, KAZUKAWA, ITSURO, SOMEYA, TOMOHIRO, WATANABE, TOMOYUKI, MINAMITANI, KANSHI, MINAGAWA, MASANORI, WATAKI, KUNIO, NISHIOKA, TADASHI, YASUDA, TOSHIYUKI
Format: Article
Language:English
Subjects:
Antithyroid Agents - therapeutic use
Antithyroid drugs
Atrophic thyroiditis
Child Development
Female
Fetal hypothyroidism
Humans
Hypothyroidism - drug therapy
Hypothyroidism - physiopathology
Infant, Newborn
Male
Maternal Graves'
disease
Neonatal hypothyroidism
Pregnancy
Pregnancy Complications - physiopathology
Prognosis
Thyroiditis, Autoimmune - drug therapy
Thyroiditis, Autoimmune - physiopathology
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Summary:We evaluated the developmental prognosis of 31 infants born to mothers with autoimmune thyroiditis. Four of the babies developed transient neonatal hypothyroidism. Their mothers all had low thyroid hormone concentrations during pregnancy. Neonatal thyroid function tended to correlate with maternal thyroid function at delivery in babies born to mothers with Graves';disease who were taking antithyroid drugs. Since severe fetal hypothyroidism sometimes results in neurological damage, it is important to maintain normal maternal thyroid function during pregnancy.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.47.SupplMarch_S133