Ehrlichiosis associated vasculitis

. Pick N, Potasman I, Strenger C, Keysary A, Schwartz I (Bnai Zion Medical Center, and Technion Faculty of Medicine, Haifa; Israel Institute for Biological Research, Ness‐Ziona, Israel; New York Medical College, USA). Ehrlichiosis associated vasculitis. J Intern Med 2000; 247: 674–678. Objective. To...

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Bibliographic Details
Published in:Journal of internal medicine 2000-06, Vol.247 (6), p.674-678
Main Authors: Pick, N., Potasman, I., Strenger, C., Keysary, A., Schwartz, I.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Bacterial - blood
Biological and medical sciences
Biopsy
Diagnosis, Differential
E. chaffeensis
Ehrlichia chaffeensis - immunology
Ehrlichia chaffeensis - isolation & purification
Ehrlichiosis - complications
Ehrlichiosis - diagnosis
Ehrlichiosis - immunology
Female
human granulocytic ehrlichiosis agent
Humans
Male
Medical sciences
Middle Aged
PCR
Polyarteritis Nodosa - microbiology
Polymerase Chain Reaction
Purpura, Schoenlein-Henoch - microbiology
Retrospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
serology
Skin - microbiology
Vasculitis - microbiology
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Summary:. Pick N, Potasman I, Strenger C, Keysary A, Schwartz I (Bnai Zion Medical Center, and Technion Faculty of Medicine, Haifa; Israel Institute for Biological Research, Ness‐Ziona, Israel; New York Medical College, USA). Ehrlichiosis associated vasculitis. J Intern Med 2000; 247: 674–678. Objective. To test the hypothesis that some cases of primary vasculitis are caused by ehrlichiosis. Design. A retrospective case study and serological analysis of stored sera. Setting. University hospital. Subjects. Fifty‐five patients discharged with any type of vasculitis over a 6‐year period. Main outcome measures. Serology for human monocytic ehrlichiosis, and the human granulocytic ehrlichiosis agent, and polymerase chain reaction (PCR) analysis of biopsy specimens. Results. Three patients (5.5%) had titres of 1 : 128 or higher against E. chaffeensis; none was positive for the human granulocytic ehrlichiosis agent. Skin biopsies of these patients showed lesions compatible with polyarteritis nodosa, allergic purpura and unspecified vasculitis. PCR analysis of the biopsies was unrevealing. Conclusions. Infection with human monocytic ehrlichiosis may underlie some forms of vasculitis. If confirmed, these findings may help identify patients with vasculitis who would benefit from antibiotic treatment.
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.2000.00680.x