Association of Antibiotic Utilization Measures and Control of Multiple‐Drug Resistance in Klebsiella pneumoniae

To study the association of antibiotic-utilization measures and control of multidrug-resistant (MDR) Klebsiella pneumoniae after emergence in two hospitals in our medical center. Rates of MDR K. pneumoniae at two hospitals were compared before and after acute interventions, including emphasis on Con...

Full description

Saved in:
Bibliographic Details
Published in:Infection control and hospital epidemiology 2000-07, Vol.21 (7), p.455-458
Main Authors: Patterson, Jan E., Hardin, Thomas C., Kelly, Cindy A., Garcia, Rosa C., Jorgensen, James H.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cephalosporins
Cross Infection
Data lines
DNA, Bacterial - analysis
Drug resistance
Drug Resistance, Multiple
Education
Electrophoresis, Gel, Pulsed-Field
Epidemiology
Hospitals
Humans
Infection control
Infection Control - methods
Infectious diseases
Klebsiella Infections - drug therapy
Klebsiella Infections - transmission
Klebsiella pneumoniae
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - genetics
Klebsiella pneumoniae - pathogenicity
Lactams
Medical sciences
Nursing
Original Articles
Pathogens
Pharmacology. Drug treatments
Physicians
Total costs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To study the association of antibiotic-utilization measures and control of multidrug-resistant (MDR) Klebsiella pneumoniae after emergence in two hospitals in our medical center. Rates of MDR K. pneumoniae at two hospitals were compared before and after acute interventions, including emphasis on Contact Precautions and education in antibiotic utilization. Antipseudomonal beta-lactam antibiotic use was measured before and after the interventions at both hospitals. Pulsed-field gel electrophoresis of whole cell DNA was used as a marker of strain identity. Clonal strain dissemination was the major mechanism of emergence at hospital A; emergence was polyclonal at hospital B. Antibiotic-utilization interventions at both institutions included physician education regarding the association of ceftazidime use and MDR K. pneumoniae. At hospital A, ceftazidime use decreased from 4,301 g in the preintervention period, to 1,248 g in the postintervention period. Piperacillin-tazobactam use increased from 12,455 g to 17,464 g. Ceftazidime resistance in K. pneumoniae decreased from 110 (22%) of 503 isolates to 61 (15%) of 407 isolates (P
ISSN:0899-823X
1559-6834
DOI:10.1086/501787