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New biocompatible polymer surface coating for stents results in a low neointimal response
Clinical studies indicate a more pronounced endothelial response after stent implantation than after balloon inflation. This might be related to the metal surface of the stent, and therefore it is speculated that coating of the stent might partially prevent hyperplasia. One coated and one noncoated...
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Published in: | Journal of biomedical materials research 2000-10, Vol.52 (1), p.193-198 |
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description | Clinical studies indicate a more pronounced endothelial response after stent implantation than after balloon inflation. This might be related to the metal surface of the stent, and therefore it is speculated that coating of the stent might partially prevent hyperplasia. One coated and one noncoated Palmaz‐Schatz stent were implanted in two separate coronary arteries of seven pigs. The coating was composed of methylmethacrylate (MMA) (hydrophobic, 70 mol %) and 2‐hydroxyethyl methacrylate (HEMA) (hydrophilic 30 mol %). After sacrifice (3 weeks), cross sections were made of the stented areas. Vessel wall reaction was calculated both independently and dependently of local vessel wall injury due to the stent struts. Overall, vessel wall reaction of the coated stents was lower than that of the noncoated stents. The degree of hyperplasia was linearly related to the degree of stent‐induced vessel wall injury. Analyses of all the struts showed that significantly less hyperplasia occurred in the coated versus noncoated stents. In this porcine coronary artery model, the MMA/HEMA stent coating resulted in significantly reduced vessel wall response. However, it remains to be determined whether this favorable outcome will also be present in humans. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 193–198, 2000. |
doi_str_mv | 10.1002/1097-4636(200010)52:1<193::AID-JBM25>3.0.CO;2-7 |
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This might be related to the metal surface of the stent, and therefore it is speculated that coating of the stent might partially prevent hyperplasia. One coated and one noncoated Palmaz‐Schatz stent were implanted in two separate coronary arteries of seven pigs. The coating was composed of methylmethacrylate (MMA) (hydrophobic, 70 mol %) and 2‐hydroxyethyl methacrylate (HEMA) (hydrophilic 30 mol %). After sacrifice (3 weeks), cross sections were made of the stented areas. Vessel wall reaction was calculated both independently and dependently of local vessel wall injury due to the stent struts. Overall, vessel wall reaction of the coated stents was lower than that of the noncoated stents. The degree of hyperplasia was linearly related to the degree of stent‐induced vessel wall injury. Analyses of all the struts showed that significantly less hyperplasia occurred in the coated versus noncoated stents. In this porcine coronary artery model, the MMA/HEMA stent coating resulted in significantly reduced vessel wall response. However, it remains to be determined whether this favorable outcome will also be present in humans. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 193–198, 2000.</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/1097-4636(200010)52:1<193::AID-JBM25>3.0.CO;2-7</identifier><identifier>PMID: 10906692</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biocompatibility ; Biocompatible Materials ; Biological and medical sciences ; Blood vessels ; Cell Division ; coating ; Coatings ; Coronary Vessels - pathology ; Coronary Vessels - surgery ; hyperplasia ; Implants (surgical) ; Medical sciences ; MMA/HEMA ; Numerical analysis ; polymer ; Polymers ; Statistical methods ; stent ; Stents ; Surface Properties ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Swine ; Transplantation (surgical) ; Tunica Intima - pathology ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>Journal of biomedical materials research, 2000-10, Vol.52 (1), p.193-198</ispartof><rights>Copyright © 2000 John Wiley & Sons, Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 John Wiley & Sons, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5485-c9ab34b1e2c29daac212be074f641e393113e243c92341d09e9f0ca998aedf6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1466344$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10906692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bär, Frits W.</creatorcontrib><creatorcontrib>van der Veen, Frederik H.</creatorcontrib><creatorcontrib>Benzina, Abder</creatorcontrib><creatorcontrib>Habets, Jo</creatorcontrib><creatorcontrib>Koole, Leo H.</creatorcontrib><title>New biocompatible polymer surface coating for stents results in a low neointimal response</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Clinical studies indicate a more pronounced endothelial response after stent implantation than after balloon inflation. This might be related to the metal surface of the stent, and therefore it is speculated that coating of the stent might partially prevent hyperplasia. One coated and one noncoated Palmaz‐Schatz stent were implanted in two separate coronary arteries of seven pigs. The coating was composed of methylmethacrylate (MMA) (hydrophobic, 70 mol %) and 2‐hydroxyethyl methacrylate (HEMA) (hydrophilic 30 mol %). After sacrifice (3 weeks), cross sections were made of the stented areas. Vessel wall reaction was calculated both independently and dependently of local vessel wall injury due to the stent struts. Overall, vessel wall reaction of the coated stents was lower than that of the noncoated stents. The degree of hyperplasia was linearly related to the degree of stent‐induced vessel wall injury. Analyses of all the struts showed that significantly less hyperplasia occurred in the coated versus noncoated stents. In this porcine coronary artery model, the MMA/HEMA stent coating resulted in significantly reduced vessel wall response. However, it remains to be determined whether this favorable outcome will also be present in humans. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 193–198, 2000.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Blood vessels</subject><subject>Cell Division</subject><subject>coating</subject><subject>Coatings</subject><subject>Coronary Vessels - pathology</subject><subject>Coronary Vessels - surgery</subject><subject>hyperplasia</subject><subject>Implants (surgical)</subject><subject>Medical sciences</subject><subject>MMA/HEMA</subject><subject>Numerical analysis</subject><subject>polymer</subject><subject>Polymers</subject><subject>Statistical methods</subject><subject>stent</subject><subject>Stents</subject><subject>Surface Properties</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Swine</subject><subject>Transplantation (surgical)</subject><subject>Tunica Intima - pathology</subject><subject>Vascular surgery: aorta, extremities, vena cava. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Swine</topic><topic>Transplantation (surgical)</topic><topic>Tunica Intima - pathology</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>online_resources</toplevel><creatorcontrib>Bär, Frits W.</creatorcontrib><creatorcontrib>van der Veen, Frederik H.</creatorcontrib><creatorcontrib>Benzina, Abder</creatorcontrib><creatorcontrib>Habets, Jo</creatorcontrib><creatorcontrib>Koole, Leo H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bär, Frits W.</au><au>van der Veen, Frederik H.</au><au>Benzina, Abder</au><au>Habets, Jo</au><au>Koole, Leo H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New biocompatible polymer surface coating for stents results in a low neointimal response</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2000-10</date><risdate>2000</risdate><volume>52</volume><issue>1</issue><spage>193</spage><epage>198</epage><pages>193-198</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>Clinical studies indicate a more pronounced endothelial response after stent implantation than after balloon inflation. This might be related to the metal surface of the stent, and therefore it is speculated that coating of the stent might partially prevent hyperplasia. One coated and one noncoated Palmaz‐Schatz stent were implanted in two separate coronary arteries of seven pigs. The coating was composed of methylmethacrylate (MMA) (hydrophobic, 70 mol %) and 2‐hydroxyethyl methacrylate (HEMA) (hydrophilic 30 mol %). After sacrifice (3 weeks), cross sections were made of the stented areas. Vessel wall reaction was calculated both independently and dependently of local vessel wall injury due to the stent struts. Overall, vessel wall reaction of the coated stents was lower than that of the noncoated stents. The degree of hyperplasia was linearly related to the degree of stent‐induced vessel wall injury. Analyses of all the struts showed that significantly less hyperplasia occurred in the coated versus noncoated stents. In this porcine coronary artery model, the MMA/HEMA stent coating resulted in significantly reduced vessel wall response. However, it remains to be determined whether this favorable outcome will also be present in humans. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 193–198, 2000.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10906692</pmid><doi>10.1002/1097-4636(200010)52:1<193::AID-JBM25>3.0.CO;2-7</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Biocompatibility Biocompatible Materials Biological and medical sciences Blood vessels Cell Division coating Coatings Coronary Vessels - pathology Coronary Vessels - surgery hyperplasia Implants (surgical) Medical sciences MMA/HEMA Numerical analysis polymer Polymers Statistical methods stent Stents Surface Properties Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Transplantation (surgical) Tunica Intima - pathology Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
title | New biocompatible polymer surface coating for stents results in a low neointimal response |
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